T cell receptor expression in Sjögren's syndrome.
T cell receptor expression in Sjögren's syndrome.
复制标题
干燥综合征中 T 细胞受体的表达。
DOI：
10.1136/ard.50.10.691
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发表时间：
1991
影响因子：
27.4
通讯作者：
D. Isenberg
中科院分区：
文献类型：
--
作者：
Alimuddin Zumla;M. Mathur;J. Stewart;L. Wilkinson;D. Isenberg
已知表达γ/δ T细胞受体的T淋巴细胞和表达CD 5的B淋巴细胞在原发性干燥综合征患者的外周血中大量出现。在2例原发性干燥综合征患者、6例继发性干燥综合征患者和7例健康对照者的唇活检标本中检查了α/β和γ/δ T细胞受体表面表型标志物CD 4、CD 8、CD 45和CD 5的细胞浸润。大多数干燥唇活检细胞浸润是表达α/β T细胞受体的CD 4亚群的T淋巴细胞（平均70%）。在干燥综合征中，嘴唇活检标本中携带γ/δ T细胞受体的细胞的低患病率保持不变（平均1.5%），因此这些携带γ/δ T细胞受体的淋巴细胞似乎不太可能在干燥综合征的免疫病理学中起主要作用。原发性和继发性干燥综合征的病灶浸润中超过70%的细胞表达CD 5和CD 45细胞表面分子。
T lymphocytes expressing the gamma/delta T cell receptor and B lymphocytes expressing CD5 are known to occur in expanded numbers in the peripheral blood of patients with primary Sjögren's syndrome. The cellular infiltrates for the surface phenotypic markers for alpha/beta and gamma/delta T cell receptors, CD4, CD8, CD45, and CD5 were examined in lip biopsy specimens from two patients with primary Sjögren's syndrome, six with secondary Sjögren's syndrome, and seven healthy controls. Most of the Sjögren's lip biopsy cellular infiltrates were T lymphocytes of the CD4 subset expressing the alpha/beta T cell receptor (mean 70%). The low prevalence of gamma/delta T cell receptor bearing cells in lip biopsy specimens is maintained in Sjögren's syndrome (mean 1.5%), and thus it seems unlikely that these lymphocytes bearing the gamma/delta T cell receptor have a major role in the immunopathology of Sjögren's syndrome. Over 70% of cells within the lesional infiltrate of primary and secondary Sjögren's syndrome expressed the CD5 and CD45 cell surface molecules.
结核菌素反应中淋巴因子产生和淋巴细胞活化抗原的免疫组织学证据。
影响因子：
4.6
作者：
Fullmer,MA;Shen,JY;Modlin,RL;Rea,TH
通讯作者：
Rea,TH
影响因子：
--
作者：
FOX, RI;CARSTENS, SA;VAUGHAN, JH
通讯作者：
VAUGHAN, JH