Voyage of theranostic liposomes for imaging and therapy
Voyage of theranostic liposomes for imaging and therapy
复制标题
用于成像和治疗的治疗诊断脂质体的旅程
DOI：
10.1080/14764172.2017.1279331
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发表时间：
2017
影响因子：
1.2
通讯作者：
S. Dinesh
中科院分区：
文献类型：
--
作者：
Mitkare Sachin;D. Sachin;S. Dinesh
摘要药物输送是任何疾病治疗中的关键问题。现在更多的努力集中在将成像剂和治疗药物整合在单一制剂中以实现同时的疾病诊断和靶向药物递送。这个新的术语“纳米治疗诊断学”已被用于描述这些纳米颗粒制剂。在古代，各种纳米载体（脂质体、纳米颗粒、树枝状聚合物、胶束、抗体等）已经被研究用于化学或生物分子的靶向递送。在这些纳米载体中，脂质体由于其独特的结构特性而被广泛研究，并提供了比其他纳米载体更多的优点。这篇综述将突出治疗诊断的概念以及临床或临床前阶段的治疗诊断脂质体制剂的一些例子。我们简要回顾了治疗诊断脂质体制剂的配制方法。
ABSTRACT Drug delivery is a critical issue in any disease treatment. Nowadays much more effort is being focused on integrating imaging agent and therapeutic drugs in a single formulation to achieve a simultaneous disease diagnosis and targeted drug delivery. This new terminology ‘nanotheranostics’ have been used to describe these nanoparticle formulations. In the ancient years, various nanocarriers (liposomes, nanoparticles, dendrimers, micelles, antibodies, etc.) have been studied for targeted delivery of chemical or biological molecules. In these nanocarriers, liposome is largely studied nanoscale delivery systems and offers more advantages than others due to their unique structural properties. This review will highlight theranostic concept as well as some examples of theranostic liposomal formulations in clinical or preclinical stages. We briefly reviewed approaches to formulate theranostic liposomal formulations.
影响因子：
10.8
作者：
Weng, Kevin C.;Noble, Charles O.;Park, John W.
通讯作者：
Park, John W.
影响因子：
18.3
作者：
Jokerst JV;Gambhir SS
通讯作者：
Gambhir SS