Comparison of True and Smoothed Puff Profile Replication on Smoking Behavior and Mainstream Smoke Emissions.
Comparison of True and Smoothed Puff Profile Replication on Smoking Behavior and Mainstream Smoke Emissions.
复制标题
真实和平滑的抽吸轮廓复制对吸烟行为和主流烟雾排放的比较。
DOI：
10.1021/tx500318h
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发表时间：
2015
影响因子：
4.1
通讯作者：
Gordon,SydneyM
中科院分区：
文献类型：
--
作者：
Brinkman,MarielleC;Kim,Hyoshin;Chuang,JaneC;Kroeger,RobynR;Deojay,Dawn;Clark,PamelaI;Gordon,SydneyM
为了估计吸烟者从香烟中的暴露，通常测量吸烟地形并将其编程到吸烟机中以模拟人类吸烟，并测试所得烟雾排放的有害成分的相对水平。然而，仅使用具有固定抽吸频率、体积和持续时间的汇总抽吸数据可能会低估或高估实际的烟雾毒素暴露。在这项实验室研究中，我们使用了一个地形图驱动的吸烟机，它忠实地再现了人类吸烟过程和在以前的临床研究中收集的个体人类地形图数据（n= 24），以研究复制真实的抽吸曲线（TP）与数学推导的平滑抽吸曲线（SM）是否会导致粒度分布和选定的毒性/致癌的有机化合物从主流烟雾排放。使用电低压冲击器测量粒度分布，通过重量分析法确定粒度分级的细颗粒和超细颗粒的质量，并分析收集的颗粒中所选的颗粒结合的半挥发性化合物。使用质子转移反应-质谱仪在真实的时间内测量挥发性化合物。总的来说，TP水平的细和超细颗粒质量以及颗粒结合的有机化合物略低于SM浓度。相比之下，挥发性化合物没有显示出明显的趋势。由于使用TP和SM剖面而导致的排放差异通常不足以保证放弃用于生成更简单的平滑剖面的程序而支持真实剖面。
To estimate exposures to smokers from cigarettes, smoking topography is typically measured and programmed into a smoking machine to mimic human smoking, and the resulting smoke emissions are tested for relative levels of harmful constituents. However, using only the summary puff datawith a fixed puff frequency, volume, and durationmay underestimate or overestimate actual exposure to smoke toxins. In this laboratory study, we used a topography-driven smoking machine that faithfully reproduces a human smoking session and individual human topography data (n= 24) collected during previous clinical research to investigate if replicating the true puff profile (TP) versus the mathematically derived smoothed puff profile (SM) resulted in differences in particle size distributions and selected toxic/carcinogenic organic compounds from mainstream smoke emissions. Particle size distributions were measured using an electrical low pressure impactor, the masses of the size-fractionated fine and ultrafine particles were determined gravimetrically, and the collected particulate was analyzed for selected particle-bound, semivolatile compounds. Volatile compounds were measured in real time using a proton transfer reaction-mass spectrometer. By and large, TP levels for the fine and ultrafine particulate masses as well as particle-bound organic compounds were slightly lower than the SM concentrations. The volatile compounds, by contrast, showed no clear trend. Differences in emissions due to the use of the TP and SM profiles are generally not large enough to warrant abandoning the procedures used to generate the simpler smoothed profile in favor of the true profile.
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DOI：
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发表时间：
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期刊：
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影响因子：
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影响因子：
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DOI：
10.1093/jn/112.2.283
发表时间：
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期刊：
The Journal of nutrition
影响因子：
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作者：
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