Disease burden of methylmercury in the German birth cohort 2014.
Disease burden of methylmercury in the German birth cohort 2014.
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DOI：
10.1371/journal.pone.0190409
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Greiner M
中科院分区：
文献类型：
--
作者：
Lackner J;Weiss M;Müller-Graf C;Greiner M
本研究旨在估算2014年在德国出生的儿童的甲基汞疾病负担。人类主要在吃鱼或海鲜时接触甲基汞。产前接触甲基汞与智商下降有关。为了量化这种疾病负担，我们根据经验数据使用蒙特卡罗模拟来估计食用鱼类的母亲所生的孩子轻度和重度智力低下的发生率。随后，我们用伤残调整生命年（DALY）方法计算了疾病负担。伤残调整生命年将死亡率和发病率结合在一起，量化理想情况（即全体人口在没有疾病和残疾的情况下达到标准预期寿命）与实际情况之间的差距。因此，一个伤残调整生命年相当于失去一年的健康寿命。 2014 年德国出生队列中甲基汞引起的疾病负担平均为 14,186 DALY（95% CI 12,915–15,440 DALY）。与死亡率相比，大部分伤残调整生命年归因于发病率。在总疾病负担中，98%归因于轻度智力低下，这只会导致发病。其余的疾病负担是严重智力低下造成的，过早死亡和发病的比例相同。
This study aimed to estimate the disease burden of methylmercury for children born in Germany in the year 2014. Humans are mainly exposed to methylmercury when they eat fish or seafood. Prenatal methylmercury exposure is associated with IQ loss. To quantify this disease burden, we used Monte Carlo simulation to estimate the incidence of mild and severe mental retardation in children born to mothers who consume fish based on empirical data. Subsequently, we calculated the disease burden with the disability-adjusted life years (DALY)-method. DALYs combine mortality and morbidity in one measure and quantify the gap between an ideal situation, where the entire population experiences the standard life expectancy without disease and disability, and the actual situation. Thus, one DALY corresponds to the loss of one year of life in good health. The methylmercury-induced burden of disease for the German birth cohort 2014 was an average of 14,186 DALY (95% CI 12,915–15,440 DALY). A large majority of the DALYs was attributed to morbidity as compared to mortality. Of the total disease burden, 98% were attributed to mild mental retardation, which only leads to morbidity. The remaining disease burden was a result of severe mental retardation with equal proportions of premature death and morbidity.
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影响因子：
10.4
作者：
Canuel R;de Grosbois SB;Atikessé L;Lucotte M;Arp P;Ritchie C;Mergler D;Chan HM;Amyot M;Anderson R
通讯作者：
Anderson R
影响因子：
10.4
作者：
Axelrad, Daniel A;Bellinger, David C;Ryan, Louise M;Woodruff, Tracey J
通讯作者：
Woodruff, Tracey J
DOI：
10.1078/1438-4639-00155
发表时间：
2002-05-01
影响因子：
6
作者：
Becker, K;Kaus, S;Seifert, B
通讯作者：
Seifert, B
DOI：
10.1093/gerona/57.7.m470
发表时间：
2002-07-01
影响因子：
5.1
作者：
Bittles, AH;Petterson, BA;Montgomery, PD
通讯作者：
Montgomery, PD
影响因子：
3.8
作者：
Castoldi, AF;Coccini, T;Manzo, L
通讯作者：
Manzo, L