[3H]MK801 binding to the NMDA receptor/ionophore complex is regulated by divalent cations: evidence for multiple regulatory sites.
[3H]MK801 binding to the NMDA receptor/ionophore complex is regulated by divalent cations: evidence for multiple regulatory sites.
复制标题
[3H]MK801 与 NMDA 受体/离子载体复合物的结合受二价阳离子调节：多个调节位点的证据。
DOI：
10.1016/0014-2999(88)90697-8
复制
发表时间：
1988
影响因子：
5
通讯作者：
Miller,RJ
中科院分区：
文献类型：
--
作者：
Reynolds,IJ;Miller,RJ
We have examined the ability of divalent and trivalent cations to regulate [3H]MK801 binding to the N-methyl-D- aspartate operated ionophore of rat brain membranes. In EDTA-washed membranes that are nominally free of glutamate and glycine the cations Ba2+, Ca2+, Co2+, La3+, Mn2+,and Sr2+increased [3H]MK801 binding in the range 0.01–10 mM, depending on the cation studied. At higher concentrations (0.1–30 mM) these cations all inhibited binding. In contrast, Cd2+, Hg2+, Mg2+, Ni2+and Zn2+inhibited binding at all concentrations tested. The addition of maximally effective concentrations of glutamate (100 μM) and glycine (30 μM) increased binding by some 200% above control. In the presence of glutamate and glycine all cations except Sr2+only inhibited binding, while the stimulation produced by Sr2+was markedly diminished. The potency of most of the divalent cations tested was increased in the presence of glutamate and glycine. In contrast, Cd2+and Zn2+became less potent, while the potency of Hg2+did not change. Thus, it appears that cations regulate the function of the N-methyl-D-aspartate receptor/ ionophore complex by interacting with at least two separate sites.
登录
查看更多内容
兴奋性氨基酸递质的药理学。
DOI：
--
发表时间：
1981
期刊：
Advances in biochemical psychopharmacology
影响因子：
--
作者：
J. Watkins
通讯作者：
J. Watkins
新型抗惊厥药 MK-801 与大鼠大脑中的中枢苯环己哌啶识别位点相互作用。
影响因子：
5
作者：
P. Loo;A. Braunwalder;Michael Williams;M. Sills
通讯作者：
M. Sills
镁离子抑制小脑颗粒细胞原代培养物中内源兴奋性氨基酸对肌醇磷脂水解的刺激
影响因子：
4.7
作者：
F. Nicoletti;J. Wroblewski;E. Costa
通讯作者：
E. Costa
N-甲基-d-天冬氨酸受体拮抗剂 d-(−)-2-氨基-5-磷酸戊酸对苯环己哌啶/σ-受体的非竞争性调节
影响因子：
2.5
作者：
D. Javitt;A. Jotkowitz;R. Sircar;S. Zukin
通讯作者：
S. Zukin
DOI：
10.1073/pnas.84.21.7744
发表时间：
1987-11-01
影响因子：
11.1
作者：
REYNOLDS, IJ;MURPHY, SN;MILLER, RJ
通讯作者：
MILLER, RJ