Tigecycline therapy for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria leads to tigecycline resistance.
Tigecycline therapy for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria leads to tigecycline resistance.
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DOI：
10.1111/1469-0691.12714
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Bonomo RA
中科院分区：
文献类型：
--
作者：
van Duin D;Cober ED;Richter SS;Perez F;Cline M;Kaye KS;Kalayjian RC;Salata RA;Evans SR;Fowler VG Jr;Bonomo RA
耐碳青霉烯类肺炎克雷伯菌（CRKP）是一种日益严重的全球性威胁。在此，我们描述了一项多中心前瞻性研究中CRKP菌尿患者队列中替加环素使用的患病率和影响。在21个月的研究期间，纳入了260例独特患者。替加环素用于80例（31%）患者。首次住院期间使用替加环素与同一患者随后发生替加环素耐药显著相关（OR 6.13，95%CI 1.15-48.65，p=0.03）。总之，替加环素用于CRKP菌尿症很常见，并且与替加环素耐药的后续发展相关。
Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an increasing global threat. Here, we describe the prevalence and impact of tigecycline use in a cohort of patients with CRKP bacteriuria nested within a multicenter, prospective study. In the 21 month study period, 260 unique patients were included. Tigecycline was given to 80 (31%) patients. The use of tigecycline during the index hospitalization was significantly associated with the subsequent development of tigecycline resistance in the same patient (OR 6.13, 95%CI 1.15–48.65, p=0.03). In conclusion, the use of tigecycline with CRKP bacteriuria is common, and is associated with the subsequent development of tigecycline resistance.
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影响因子：
5.2
作者：
Lopez-Camacho, Elena;Gomez-Gil, Rosa;Mingorance, Jesus
通讯作者：
Mingorance, Jesus
影响因子：
4.5
作者：
Braykov, Nikolay P.;Eber, Michael R.;Laxminarayan, Ramanan
通讯作者：
Laxminarayan, Ramanan
影响因子：
4.9
作者：
Nigo, Masayuki;Cevallos, Catalina Salinas;Ruhe, Joerg J.
通讯作者：
Ruhe, Joerg J.
影响因子：
4.9
作者：
Horan, Teresa C.;Andrus, Mary;Dudeck, Margaret A.
通讯作者：
Dudeck, Margaret A.
影响因子：
4.9
作者：
Sader, Helio S.;Farrell, David J.;Jones, Ronald N.
通讯作者：
Jones, Ronald N.