Role of Nod2 in the development of Crohn's disease.

Role of Nod2 in the development of Crohn's disease.
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DOI:
10.1016/j.micinf.2009.06.005
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发表时间:
2009-10
影响因子:
5.8
通讯作者:
Ma X
Ma X
中科院分区:
医学3区
文献类型:
--
作者:
Yamamoto S;Ma X

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克罗恩病(CD)是由免疫器官的调节能力丧失引起的。Nod2是一种细胞内细菌传感器,其突变与CD的发展相关。在这里,我们总结了最近的和有争议的研究结果的作用的Nod2突变体在疾病的过程中。
Crohn’s Disease (CD) is caused by a loss of the regulatory capacity of the immune apparatus. Nod2 is an intracellular bacterial sensor and its mutations are associated with the development of CD. Here we summarize recent and controversial findings about the role of the Nod2 mutants in the disease process.
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