The microbial metabolite desaminotyrosine protects from influenza through type I interferon.
The microbial metabolite desaminotyrosine protects from influenza through type I interferon.
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DOI：
10.1126/science.aam5336
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发表时间：
2017-08-04
期刊：
影响因子：
--
通讯作者：
Stappenbeck TS
中科院分区：
文献类型：
--
作者：
Steed AL;Christophi GP;Kaiko GE;Sun L;Goodwin VM;Jain U;Esaulova E;Artyomov MN;Morales DJ;Holtzman MJ;Boon ACM;Lenschow DJ;Stappenbeck TS
The microbiota is known to modulate the host response to influenza infection through as-yet-unclear mechanisms. We hypothesized that components of the microbiota exert effects through type I interferon (IFN), a hypothesis supported by analysis of influenza in a gain-of-function genetic mouse model. Here we show that a microbially associated metabolite, desaminotyrosine (DAT), protects from influenza through augmentation of type I IFN signaling and diminution of lung immunopathology. A specific human-associated gut microbe, Clostridium orbiscindens, produced DAT and rescued antibiotic-treated influenza-infected mice. DAT protected the host by priming the amplification loop of type I IFN signaling. These findings show that specific components of the enteric microbiota have distal effects on responses to lethal infections through modulation of type I IFN.
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