Tunable vapor-condensed nanolenses.
Tunable vapor-condensed nanolenses.
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DOI：
10.1021/nn502453h
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发表时间：
2014-07-22
期刊：
影响因子：
17.1
通讯作者：
Ozcan, Aydogan
中科院分区：
文献类型：
--
作者：
McLeod, Euan;Chau Nguyen;Huang, Patrick;Luo, Wei;Veli, Muhammed;Ozcan, Aydogan
纳米结构化光学部件，例如纳米透镜，以亚波长尺度引导光，以实现高分辨率光刻、光子电路的小型化和生物结构的纳米级成像等。制造纳米透镜的一个主要挑战是透镜相对于样品的适当定位，同时确保其采用用于预期用途的最佳尺寸和形状。特别感兴趣的一个应用是在纳米级物体的成像中增强对比度和信噪比，特别是在宽视场（FOV）上，其通常具有用于成像纳米物体的有限分辨率和灵敏度。在这里，我们提出了一种用于制造时间和温度可调的纳米透镜的自组装方法，该方法基于聚合物液体在纳米颗粒周围的冷凝，我们将其应用于小于40 nm的球状体、直径小于20 nm的棒状颗粒和生物功能化纳米颗粒的高通量片上检测，所有这些都跨越了>20 mm 2的超大FOV。先前在类似FOV上的纳米颗粒成像工作已经检测到不小于100 nm的球状体，因此我们的结果证明了体积小15倍的颗粒的检测，与早期宽场成像工作中检测到的颗粒尺寸相比，其在自由空间中具有弱240倍的瑞利散射。该整个平台具有可调纳米透镜冷凝和宽场成像功能，也被小型化为具有成本效益的便携式设备，这对于现场使用、移动的感测和诊断应用（包括例如体液中病毒载量的测量）可能特别重要。
Nanostructured optical components, such as nanolenses, direct light at subwavelength scales to enable, among others, high-resolution lithography, miniaturization of photonic circuits, and nanoscopic imaging of biostructures. A major challenge in fabricating nanolenses is the appropriate positioning of the lens with respect to the sample while simultaneously ensuring it adopts the optimal size and shape for the intended use. One application of particular interest is the enhancement of contrast and signal-to-noise ratio in the imaging of nanoscale objects, especially over wide fields-of-view (FOVs), which typically come with limited resolution and sensitivity for imaging nano-objects. Here we present a self-assembly method for fabricating time- and temperature-tunable nanolenses based on the condensation of a polymeric liquid around a nanoparticle, which we apply to the high-throughput on-chip detection of spheroids smaller than 40 nm, rod-shaped particles with diameter smaller than 20 nm, and biofunctionalized nanoparticles, all across an ultralarge FOV of >20 mm2. Previous nanoparticle imaging efforts across similar FOVs have detected spheroids no smaller than 100 nm, and therefore our results demonstrate the detection of particles >15-fold smaller in volume, which in free space have >240 times weaker Rayleigh scattering compared to the particle sizes detected in earlier wide-field imaging work. This entire platform, with its tunable nanolens condensation and wide-field imaging functions, is also miniaturized into a cost-effective and portable device, which might be especially important for field use, mobile sensing, and diagnostics applications, including, for example, the measurement of viral load in bodily fluids.
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影响因子：
6.1
作者：
Bishara W;Sikora U;Mudanyali O;Su TW;Yaglidere O;Luckhart S;Ozcan A
通讯作者：
Ozcan A
影响因子：
3.8
作者：
Greenbaum A;Ozcan A
通讯作者：
Ozcan A
影响因子：
8.6
作者：
Blaschke, Johannes;Lapp, Tobias;Vollmer, Juergen
通讯作者：
Vollmer, Juergen
影响因子：
3.8
作者：
Huo, Yijie;Fesenmaier, Christian C.;Catrysse, Peter B.
通讯作者：
Catrysse, Peter B.
影响因子：
10.8
作者：
Dantham, Venkata R.;Holler, Stephen;Arnold, Stephen
通讯作者：
Arnold, Stephen