IEO model: A novel concept describing the complete metastatic process in the liver microenvironment.
IEO model: A novel concept describing the complete metastatic process in the liver microenvironment.
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IEO模型：描述肝脏微环境中完整转移过程的新概念。
DOI：
10.3892/ol.2020.11525
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发表时间：
2020-04
期刊：
影响因子：
2.9
通讯作者：
Yuan Xianglin
中科院分区：
文献类型：
--
作者：
Wang Lu;Sun Yinan;Yi Minxiao;Zhao Weiheng;Yuan Xianglin
转移是恶性肿瘤细胞的特征性行为。它由原发肿瘤细胞与转移部位（特别是肝、骨、肺和脑）微环境状态之间的相互作用决定。在本综述中，定义了一种新的模式，称为IEO模型（prI-，prE-和pOst-转移小生境），肝转移微环境的特点是完整的转移过程。在IEO模型中，肝转移灶的组成部分，包括细胞外基质、肝细胞、间充质细胞、枯否细胞、肝窦内皮细胞、肝星状细胞和免疫细胞，在肝转移的不同阶段被肿瘤细胞不断重塑以形成不同的微环境。IEO模型解释了肝脏微环境的可塑性，并提供了新的见解转移小生境的不同阶段的作用。这一新的概念可能为理论癌症研究的进展和恶性肿瘤全程管理的改进提供基础。
Metastasis is a characteristic behavior of malignant tumor cells. It is determined by the mutual interaction between primary tumor cells and the state of the microenvironment at sites of metastasis, particularly the liver, bone, lungs and brain. In the present review, a novel pattern is defined and termed the IEO model (prI-, prE- and pOst-metastatic niche), for the hepatic metastatic microenvironment which characterizes the complete metastatic process. In the IEO model, the components of the hepatic metastatic niche, including the extracellular matrix, hepatocytes, mesenchymal cells, Kupffer cells, hepatic sinusoidal endothelial cells, hepatic stellate cells and immunocytes are continually remodelled by tumor cells to form various microenvironments during different stages of hepatic metastasis. The IEO model explains the plasticity of the hepatic microenvironment and provides novel insights into the role of different stages of the metastatic niche. This novel concept may provide a basis for advances in theoretical cancer research and for improvements in the complete course management of malignant tumors.
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影响因子：
4.3
作者：
Qiu, Hai-Bo;Zhang, Li-Yi;Xu, Rui-Hua
通讯作者：
Xu, Rui-Hua
影响因子：
--
作者：
Budczies J;von Winterfeld M;Klauschen F;Bockmayr M;Lennerz JK;Denkert C;Wolf T;Warth A;Dietel M;Anagnostopoulos I;Weichert W;Wittschieber D;Stenzinger A
通讯作者：
Stenzinger A
影响因子：
0.8
作者：
G. Li Destri;M. Castaing;F. Ferlito;V. Minutolo;A. Di Cataldo;S. Puleo
通讯作者：
G. Li Destri;M. Castaing;F. Ferlito;V. Minutolo;A. Di Cataldo;S. Puleo
影响因子：
3.4
作者：
G. Seitz
通讯作者：
G. Seitz
影响因子：
50.3
作者：
Steele CW;Karim SA;Leach JDG;Bailey P;Upstill-Goddard R;Rishi L;Foth M;Bryson S;McDaid K;Wilson Z;Eberlein C;Candido JB;Clarke M;Nixon C;Connelly J;Jamieson N;Carter CR;Balkwill F;Chang DK;Evans TRJ;Strathdee D;Biankin AV;Nibbs RJB;Barry ST;Sansom OJ;Morton JP
通讯作者：
Morton JP