Calcium-dependent regulation of protein synthesis in intact mammalian cells.
Calcium-dependent regulation of protein synthesis in intact mammalian cells.
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完整哺乳动物细胞中蛋白质合成的钙依赖性调节。
DOI：
10.1146/annurev.ph.52.030190.003045
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发表时间：
1990
影响因子：
18.2
通讯作者：
Brostrom,MA
中科院分区：
文献类型：
--
作者：
Brostrom,CO;Brostrom,MA
大量文献描述了蛋白质的合成和加工；内分泌和代谢基础，各种激素、机械和营养影响影响细胞功能和适应性反应；以及介导协调一致的细胞内控制的各种调节机制。尽管如此，我们目前对蛋白质合成调节和服从细胞整体代谢和刺激反应状态的机制的理解还不够。内质网是这些问题的核心。内质网在蛋白质合成调节中的潜在作用很大程度上尚未被探索。在这篇相当推测性的综述中，我们主要基于我们自己的数据，试图提出内质网通过对隔离的 Ca2+ 敏感的机制来调节翻译速率的观点。细胞适应 Ca2+ 剥夺以恢复合理的蛋白质合成速率的补偿途径也集中在内质网上。通过进一步的研究，网状 Ca2+ 储存、蛋白质加工和翻译控制机制之间存在的潜在关系应该变得更加明显。如果隔离的 Ca2+ 参与源自内质网的生物控制机制，则将 Ca2+ 作为细胞质过程调节剂的普遍观点可能需要一些扩展。实际上，胞质游离 Ca2+ 支持的过程与阳离子隔离存储促进的过程之间可能存在相互关系。据推测，这种互惠性将允许能量从一组过程快速转移到另一组过程。可以想象，隔离位点的慢性 Ca2+ 负荷可能与涉及组织肥大的某些细胞适应性 Ca2+ 负荷有关。拉伸引起的反应的潜在例子包括高血压时小动脉平滑肌壁增厚 (8) 和主动脉瓣狭窄时心脏肥大 (46)。
Extensive bodies of literature describe protein synthesis and processing; the endocrinology and metabolic bases whereby a variety of hormonal, mechanical, and nutritional influences affect cell function and adaptive responses; and various regulatory mechanisms mediating concerted intracellular control. Nonetheless, our current understanding of the mechanisms responsible for the regulation and subordination of protein synthesis to the overall metabolic and stimulus-response status of the cell is inadequate. The endoplasmic reticulum is central to these concerns. Potential roles of the endoplasmic reticulum in the regulation of protein synthesis are largely unexplored. We have attempted in this rather speculative review, based largely on our own data, to project a view of the endoplasmic reticulum as moderating the rate of translation through a mechanism sensitive to sequestered Ca2+. Compensatory routes whereby cells accommodate to Ca2+ deprivation so as to resume reasonable rates of protein synthesis are seen also to focus on the endoplasmic reticulum. With additional research, the underlying relationships that exist among reticular Ca2+ storage, protein processing, and mechanisms of translational control should become more broadly evident. The prevailing view of Ca2+ as a regulator of cytosolic processes may require some extension if sequestered Ca2+ participates in biological control mechanisms emanating from the endoplasmic reticulum. In effect, a reciprocal relationship would presumably exist among processes supported by cytosolic free Ca2+ vs those promoted by sequestered stores of the cation. Speculatively, such reciprocity would allow the rapid diversion of energy from one set of processes to the other. Conceivably, chronic Ca2+ loading at sequestered sites may be related to certain cellular adaptive Ca2+ loading involving tissue hypertrophy. Potential examples of stretch-induced responses that could be cited include thickening of arteriolar smooth muscle walls in hypertension (8) and cardiac hypertrophy in aortic stenosis (46).
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DOI：
10.1016/s0021-9258(17)42556-7
发表时间：
1984-12
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
P. Albert;A. Tashjian
通讯作者：
P. Albert;A. Tashjian
DOI：
10.1016/s0021-9258(18)45377-x
发表时间：
1987-12
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Angus C. Nairnz;C. Palfrey
通讯作者：
Angus C. Nairnz;C. Palfrey
离体大鼠肝细胞生物合成脂肪酸合成酶。
DOI：
10.1016/s0021-9258(18)91896-x
发表时间：
1969
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
D. N. Burton;J. Collins;J. Porter
通讯作者：
J. Porter
[46] 产生激素的垂体细胞的克隆株
DOI：
--
发表时间：
1979
期刊：
影响因子：
--
作者：
A. Tashjian
通讯作者：
A. Tashjian
真核细胞翻译起始时蛋白质合成的钙依赖性调节。
DOI：
--
发表时间：
1987
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Chin,KV;Cade,C;Brostrom,CO;Galuska,EM;Brostrom,MA
通讯作者：
Brostrom,MA