Relationship between environmental phthalate exposure and the intelligence of school-age children.
Relationship between environmental phthalate exposure and the intelligence of school-age children.
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DOI：
10.1289/ehp.0901376
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发表时间：
2010-07
影响因子：
10.4
通讯作者：
Kim HW
中科院分区：
文献类型：
--
作者：
Cho SC;Bhang SY;Hong YC;Shin MS;Kim BN;Kim JW;Yoo HJ;Cho IH;Kim HW
由于邻苯二甲酸盐对人类的潜在毒性，人们对邻苯二甲酸盐的担忧已经出现。我们调查了邻苯二甲酸酯代谢物的尿浓度和儿童的智力功能之间的关系。这项研究在韩国五个城市的九所小学招募了667名儿童。进行了尿邻苯二甲酸酯浓度的横断面检查，并从儿童及其母亲那里获得了神经心理学测试的分数。我们测量了尿液样本中邻苯二甲酸单-2-乙基己酯（MEHP）和邻苯二甲酸单（2-乙基-5-氧代己基）酯（MEOHP）（均为邻苯二甲酸二（2-乙基己基）酯（DEHP）的代谢物）以及邻苯二甲酸单正丁酯（MBP）（邻苯二甲酸二丁酯（DBP）的代谢物）。MEHP、MEOHP和MBP的几何平均（ln）浓度分别为21.3 μg/L [几何SD（GSD）= 2.2 μg/L;范围：0.5-445.4]、18.0 μg/L（GSD = 2.4;范围：0.07-291.1）和48.9 μg/L（GSD = 2.2;范围：2.1-1645.5）。在调整人口统计学和发育协变量后，全量表智商和言语智商评分与DEHP代谢物呈负相关，但与DBP代谢物无关。我们还发现，DEHP和DBP的代谢产物的尿液浓度与儿童的词汇分项得分之间存在显着的负相关关系。在控制了母亲的智商后，DEHP代谢物和词汇子量表得分之间仍然存在显著的负相关关系。在男孩中，我们发现MEHP邻苯二甲酸酯浓度的增加与DEHP代谢物浓度和韦氏儿童智力量表词汇评分的总和之间存在负相关;然而，在女孩中，我们发现这些变量之间没有显著相关性。控制母体智商和其他协变量，结果显示邻苯二甲酸酯代谢物和智商分数之间呈反比关系;然而，鉴于横断面流行病学的局限性，需要前瞻性研究来充分探讨这些关联。
Concern over phthalates has emerged because of their potential toxicity to humans. We investigated the relationship between the urinary concentrations of phthalate metabolites and children’s intellectual functioning. This study enrolled 667 children at nine elementary schools in five South Korean cities. A cross-sectional examination of urine phthalate concentrations was performed, and scores on neuropsychological tests were obtained from both the children and their mothers. We measured mono-2-ethylhexyl phthalate (MEHP) and mono(2-ethyl-5-oxohexyl)phthalate (MEOHP), both metabolites of di(2-ethylhexyl)phthalate (DEHP), and mono-n-butyl phthalate (MBP), a metabolite of dibutyl phthalate (DBP), in urine samples. The geometric mean (ln) concentrations of MEHP, MEOHP, and MBP were 21.3 μg/L [geometric SD (GSD) = 2.2 μg/L; range, 0.5–445.4], 18.0 μg/L (GSD = 2.4; range, 0.07–291.1), and 48.9 μg/L (GSD = 2.2; range, 2.1–1645.5), respectively. After adjusting for demographic and developmental covariates, the Full Scale IQ and Verbal IQ scores were negatively associated with DEHP metabolites but not with DBP metabolites. We also found a significant negative relationship between the urine concentrations of the metabolites of DEHP and DBP and children’s vocabulary subscores. After controlling for maternal IQ, a significant inverse relationship between DEHP metabolites and vocabulary subscale score remained. Among boys, we found a negative association between increasing MEHP phthalate concentrations and the sum of DEHP metabolite concentrations and Wechsler Intelligence Scale for Children vocabulary score; however, among girls, we found no significant association between these variables. Controlling for maternal IQ and other covariates, the results show an inverse relationship between phthalate metabolites and IQ scores; however, given the limitations in cross-sectional epidemiology, prospective studies are needed to fully explore these associations.
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影响因子：
4.7
作者：
Hays, T;Rusyn, I;Peters, JM
通讯作者：
Peters, JM
影响因子：
10.4
作者：
HINTON, RH;MITCHELL, FE;BRIDGES, JW
通讯作者：
BRIDGES, JW
影响因子：
4.1
作者：
Breous, E;Wenzel, A;Loos, U
通讯作者：
Loos, U
影响因子：
7.4
作者：
Kato, K;Silva, MJ;Calafat, AM
通讯作者：
Calafat, AM
DOI：
10.1186/1476-069x-7-27
发表时间：
2008-06-03
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Hatch EE;Nelson JW;Qureshi MM;Weinberg J;Moore LL;Singer M;Webster TF
通讯作者：
Webster TF