SARS-CoV-2 vaccines: A critical perspective through efficacy data and barriers to herd immunity.
SARS-CoV-2 vaccines: A critical perspective through efficacy data and barriers to herd immunity.
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SARS-CoV-2 疫苗： 从疗效数据和群体免疫障碍的角度看问题。
DOI：
10.1016/j.rmed.2021.106355
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发表时间：
2021-04
影响因子：
4.3
通讯作者：
Amati F
中科院分区：
文献类型：
--
作者：
Blasi F;Gramegna A;Sotgiu G;Saderi L;Voza A;Aliberti S;Amati F
事实证明，非药物干预措施和追踪检测策略不足以减少SARS-CoV-2在全球的传播。目前正在研制几种具有不同作用机制的疫苗。本文综述了在传统和下一代平台下评估SARS-CoV-2疫苗的潜在靶抗原。我们报告了来自3期试验的实验数据，重点关注了不同的功效定义以及影响SARS-CoV-2疫苗接种实际有效性的因素，包括与疫苗可获得性、交付和免疫策略相关的后勤问题。在此背景下，本文讨论了SARS-CoV-2的新变体。我们还对老年人、孕妇和免疫功能低下患者等感染或严重疾病风险较高的特殊人群接种疫苗的问题提出了批评意见。最后一段涉及鉴于疫苗开发过程长度空前缩短和批准速度加快的安全性问题。
Non-pharmacological interventions and tracing-testing strategy proved insufficient to reduce SARS-CoV-2 spreading worldwide. Several vaccines with different mechanisms of action are currently under development. This review describes the potential target antigens evaluated for SARS-CoV-2 vaccine in the context of both conventional and next-generation platforms. We reported experimental data from phase-3 trials with a focus on different definitions of efficacy as well as factors affecting real-life effectiveness of SARS-CoV-2 vaccination, including logistical issues associated to vaccine availability, delivery, and immunization strategies. On this background, new variants of SARS-CoV-2 are discussed. We also provided a critical view on vaccination in special populations at higher risk of infection or severe disease as elderly people, pregnant women and immunocompromised patients. A final paragraph addresses safety on the light of the unprecedented reduction of length of the vaccine development process and faster authorization.
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DOI：
10.1016/s1473-3099(20)30773-8
发表时间：
2021-03
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Hodgson SH;Mansatta K;Mallett G;Harris V;Emary KRW;Pollard AJ
通讯作者：
Pollard AJ
影响因子：
56.9
作者：
Cai, Yongfei;Zhang, Jun;Chen, Bing
通讯作者：
Chen, Bing
影响因子：
56.9
作者：
Kissler, Stephen M.;Tedijanto, Christine;Lipsitch, Marc
通讯作者：
Lipsitch, Marc
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
DOI：
10.4269/ajtmh.1988.38.411
发表时间：
1988-03-01
影响因子：
3.3
作者：
KLIKS, SC;NIMMANITYA, S;BURKE, DS
通讯作者：
BURKE, DS