The genetic code as expressed through relationships between mRNA structure and protein function.
The genetic code as expressed through relationships between mRNA structure and protein function.
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DOI：
10.1016/j.febslet.2013.03.002
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发表时间：
2013-04-17
期刊：
影响因子：
3.5
通讯作者：
Weeks KM
中科院分区：
文献类型：
--
作者：
Mauger DM;Siegfried NA;Weeks KM
信使RNA内的结构化RNA元件通常指导或调节活性蛋白质的细胞产生。如本文所述，RNA结构已被发现控制蛋白质生产的几乎每一个步骤：mRNA的生产和稳定性;翻译起始，延伸和终止;蛋白质折叠;和细胞定位。调节RNA元件在来自生命的每个领域的RNA中是常见的。越来越多的RNA介导的机制继续揭示mRNA结构调节翻译的新方式。我们整合了来自几种不同类型的RNA结构介导的调控的例子，提出了一个全球性的观点，表明RNA的二级和三级结构最终构成了指导和调节蛋白质生物合成的遗传密码的额外水平。
Structured RNA elements within messenger RNA often direct or modulate the cellular production of active proteins. As reviewed here, RNA structures have been discovered that govern nearly every step in protein production: mRNA production and stability; translation initiation, elongation, and termination; protein folding; and cellular localization. Regulatory RNA elements are common within RNAs from every domain of life. This growing body of RNA‐mediated mechanisms continues to reveal new ways in which mRNA structure regulates translation. We integrate examples from several different classes of RNA structure‐mediated regulation to present a global perspective that suggests that the secondary and tertiary structure of RNA ultimately constitutes an additional level of the genetic code that both guides and regulates protein biosynthesis.
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影响因子：
3.5
作者：
Diatchenko, L;Slade, GD;Maixner, W
通讯作者：
Maixner, W
影响因子：
18.3
作者：
Deigan, Katherine E.;Ferre-D'Amare, Adrian R.
通讯作者：
Ferre-D'Amare, Adrian R.
DOI：
10.1126/science.1225722
发表时间：
2012-10-19
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Frieda KL;Block SM
通讯作者：
Block SM
影响因子：
64.8
作者：
CRAIGEN, WJ;CASKEY, CT
通讯作者：
CASKEY, CT
DOI：
10.1099/vir.0.042499-0
发表时间：
2012-07
期刊：
The Journal of general virology
影响因子：
--
作者：
Firth AE;Brierley I
通讯作者：
Brierley I