L-Ascorbate biosynthesis in higher plants: the role of VTC2.

L-Ascorbate biosynthesis in higher plants: the role of VTC2.
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DOI:
10.1016/j.tplants.2008.08.005
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发表时间:
2008-11
影响因子:
20.5
通讯作者:
Clarke, Steven G.
Clarke, Steven G.
中科院分区:
生物学1区
文献类型:
--
作者:
Linster, Carole L.;Clarke, Steven G.

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In the past year, the last missing enzyme of the L-galactose pathway, the linear form of which appears to represent the major biosynthetic route to L-ascorbate (vitamin C) in higher plants, has been identified as a GDP-L-galactose phosphorylase. This enzyme catalyzes the first committed step in the synthesis of that vital antioxidant and enzyme cofactor. Here, we discuss how GDP-L-galactose phosphorylase enzymes, encoded in Arabidopsis by the paralogous VTC2 and VTC5 genes, function in concert with the other enzymes of the L-galactose pathway to provide plants the appropriate levels of L-ascorbate. We hypothesize that regulation of L-ascorbate biosynthesis might occur at more than one step and warrants further investigation to allow for the manipulation of vitamin C levels in plants.
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