Metabolic dysfunction in pulmonary hypertension: from basic science to clinical practice.
Metabolic dysfunction in pulmonary hypertension: from basic science to clinical practice.
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DOI：
10.1183/16000617.0094-2017
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发表时间：
2017-12-31
期刊：
影响因子：
--
通讯作者：
Rubin LJ
中科院分区：
文献类型：
--
作者：
Chan SY;Rubin LJ
肺动脉高压（PH）是一种常见的致命性血管疾病，其分子起源尚不清楚。PH中发生的肺血管重构的特征在于血管紧张素升高和促增殖状态，最终导致右心室功能障碍和心力衰竭。在癌症生物学的先前证据的许多方面的指导下，最近的研究已经确定代谢畸变是肺血管和右心室疾病过程的关键组成部分。鉴于需要改进PH的诊断和治疗选择，代谢示踪剂和药物的开发或再利用可以为预防甚至逆转疾病进展提供有效途径。在这篇综述中，我们描述了已知在PH中失调的代谢机制;我们探索了正在开发的先进诊断测试和成像模式，以提高对这种疾病的诊断能力;我们讨论了针对这些代谢途径的PH新兴药物。了解PH的代谢途径为改进诊断和治疗方案提供了机会http://ow.ly/pFQb30guez6
Pulmonary hypertension (PH) is an often-fatal vascular disease of unclear molecular origins. The pulmonary vascular remodelling which occurs in PH is characterised by elevated vasomotor tone and a pro-proliferative state, ultimately leading to right ventricular dysfunction and heart failure. Guided in many respects by prior evidence from cancer biology, recent investigations have identified metabolic aberrations as crucial components of the disease process in both the pulmonary vessels and the right ventricle. Given the need for improved diagnostic and therapeutic options for PH, the development or repurposing of metabolic tracers and medications could provide an effective avenue for preventing or even reversing disease progression. In this review, we describe the metabolic mechanisms that are known to be dysregulated in PH; we explore the advancing diagnostic testing and imaging modalities that are being developed to improve diagnostic capability for this disease; and we discuss emerging drugs for PH which target these metabolic pathways. Understanding metabolic pathways in PH provides opportunities for improved diagnostic and therapeutic options http://ow.ly/pFQb30guez6
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影响因子：
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发表时间：
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24.7
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5.4
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