Modelling of the Current Density Distributions during Cortical Electric Stimulation for Neuropathic Pain Treatment.
Modelling of the Current Density Distributions during Cortical Electric Stimulation for Neuropathic Pain Treatment.
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DOI：
10.1155/2018/1056132
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发表时间：
2018
影响因子：
--
通讯作者：
Parazzini M
中科院分区：
文献类型：
--
作者：
Fiocchi S;Chiaramello E;Ravazzani P;Parazzini M
在过去的二十年里，运动皮质刺激被认为是治疗神经病理性疼痛的一种有价值的替代药物治疗方法。虽然这项技术开始用于临床研究，但关于在不引起组织损伤的情况下提高其有效性的最佳设置的争论仍然存在。为此，将计算方法应用于真实的人体模型，旨在评估皮质内的电流密度分布，可以成为提供对该技术的基本理解的强大工具，并有助于临床实验方案的设计。这项研究旨在通过计算技术来评估由用于皮质刺激的真实电极阵列在大脑中诱导的电流密度分布。通过改变电极间距离、刺激特性(幅度和频率)和人体解剖模型，通过量化刺激对两个皮质目标的有效性(即有效体积和有效穿透深度)的具体指标来评估模拟结果。结果表明，所有这些参数都在某种程度上影响电流密度分布，因此在规划有效的电皮质刺激策略时必须考虑这些参数。特别是，我们的计算表明：(1)最有效的极间距离等于2 cm；(2)增加电压幅度会增加有效体积；(3)增加频率可以扩大有效体积；(4)有效穿透深度与受试者的解剖结构和电极放置严格相关。
In the last two decades, motor cortex stimulation has been recognized as a valuable alternative to pharmacological therapy for the treatment of neuropathic pain. Although this technique started to be used in clinical studies, the debate about the optimal settings that enhance its effectiveness without inducing tissue damage is still open. To this purpose, computational approaches applied to realistic human models aimed to assess the current density distribution within the cortex can be a powerful tool to provide a basic understanding of that technique and could help the design of clinical experimental protocols. This study aims to evaluate, by computational techniques, the current density distributions induced in the brain by a realistic electrode array for cortical stimulation. The simulation outcomes, summarized by specific metrics quantifying the efficacy of the stimulation (i.e., the effective volume and the effective depth of penetration) over two cortical targets, were evaluated by varying the interelectrode distance, the stimulus characteristics (amplitude and frequency), and the anatomical human model. The results suggest that all these parameters somehow affect the current density distributions and have to be therefore taken into account during the planning of effective electrical cortical stimulation strategies. In particular, our calculations show that (1) the most effective interelectrode distance equals 2 cm; (2) increasing voltage amplitudes increases the effective volume; (3) increasing frequencies allow enlarging the effective volume; and (4) the effective depth of penetration is strictly linked to both the anatomy of the subject and the electrode placement.
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影响因子：
7.7
作者：
Brunoni, Andre Russowsky;Nitsche, Michael A.;Bolognini, Nadia;Bikson, Marom;Wagner, Tim;Merabet, Lotfi;Edwards, Dylan J.;Valero-Cabre, Antoni;Rotenberg, Alexander;Pascual-Leone, Alvaro;Ferrucci, Roberta;Priori, Alberto;Boggio, Paulo Sergio;Fregni, Felipe
通讯作者：
Fregni, Felipe
影响因子：
1.9
作者：
Kowalski, T;Silny, J;Buchner, H
通讯作者：
Buchner, H
影响因子：
4.1
作者：
Fontaine, Denys;Hamani, Clement;Lozano, Andres
通讯作者：
Lozano, Andres
影响因子：
5.3
作者：
AGNEW, WF;YUEN, TGH;BULLARA, LA
通讯作者：
BULLARA, LA
影响因子：
3.5
作者：
Gosselin, Marie-Christine;Neufeld, Esra;Kuster, Niels
通讯作者：
Kuster, Niels