Mucins in pancreatic cancer and its microenvironment.
Mucins in pancreatic cancer and its microenvironment.
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DOI：
10.1038/nrgastro.2013.120
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发表时间：
2013-10
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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胰腺癌仍然是一种致命的恶性肿瘤，由于治疗耐药性、频繁复发和缺乏特异性靶向肿瘤及其支持基质的治疗策略，预后不良。失调的细胞表面蛋白驱动肿瘤转化，并被设想为介导肿瘤与其微环境之间的串扰。新兴的研究已经阐述了粘蛋白在多种生物学功能中的作用，包括通过其特征性的O-连接和N-连接寡糖（聚糖）、扩展的结构和独特的结构域增强的致瘤性、侵袭性、转移和耐药性。多个粘蛋白结构域差异地相互作用并调节肿瘤微环境的不同组分。本审查讨论：在健康、炎性和癌性条件下胰腺中各种粘蛋白的表达模式;在健康和病理条件下不同的粘蛋白的环境依赖性属性;肿瘤微环境在胰腺癌发展和/或进展中的作用;粘蛋白的诊断和/或预后功效;以及基于粘蛋白的治疗策略。总的来说，这些信息应该有助于通过探索粘蛋白家族来描述胰腺癌的复杂性，粘蛋白家族通过肿瘤细胞和微环境中的各种机制使疾病结果恶化。
Pancreatic cancer remains a lethal malignancy with poor prognosis owing to therapeutic resistance, frequent recurrence and the absence of treatment strategies that specifically target the tumour and its supporting stroma. Deregulated cell-surface proteins drive neoplastic transformations and are envisioned to mediate crosstalk between the tumour and its microenvironment. Emerging studies have elaborated on the role of mucins in diverse biological functions, including enhanced tumorigenicity, invasiveness, metastasis and drug resistance through their characteristic O-linked and N-linked oligosaccharides (glycans), extended structures and unique domains. Multiple mucin domains differentially interact and regulate different components of the tumour microenvironment. This Review discusses: the expression pattern of various mucins in the pancreas under healthy, inflammatory, and cancerous conditions; the context-dependent attributes of mucins that differ under healthy and pathological conditions; the contribution of the tumour microenvironment in pancreatic cancer development and/or progression; diagnostic and/or prognostic efficacy of mucins; and mucin-based therapeutic strategies. Overall, this information should help to delineate the intricacies of pancreatic cancer by exploring the family of mucins, which, through various mechanisms in both tumour cells and the microenvironment, worsen disease outcome.
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影响因子：
5.7
作者：
Chauhan SC;Ebeling MC;Maher DM;Koch MD;Watanabe A;Aburatani H;Lio Y;Jaggi M
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Jaggi M
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