Tonotopic distribution and inferior colliculus projection pattern of inhibitory and excitatory cell types in the lateral superior olive of Mongolian gerbils.
Tonotopic distribution and inferior colliculus projection pattern of inhibitory and excitatory cell types in the lateral superior olive of Mongolian gerbils.
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DOI：
10.1002/cne.25226
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Winters BD
中科院分区：
文献类型：
--
作者：
Mellott JG;Dhar M;Mafi A;Tokar N;Winters BD
声音定位很大程度上依赖于比较来自两只耳朵的信息的脑干神经元。外侧上橄榄（LSO）的传统作用是提取强度差异；然而，越来越明显的是，相对定时，尤其是瞬态的相对定时，也是一个重要功能。 LSO 内的细胞多样性尚未被充分了解，这可能是其多重作用的基础。 LSO 中存在甘氨酸能抑制性和谷氨酸能兴奋性主要神经元，然而，关于它们的相对分布和投射模式存在一些分歧。在这里，我们采用原位杂交来明确识别递质类型，并结合对下丘 (IC) 的投影进行逆行标记来解决这些问题。兴奋性 LSO 神经元的数量（76%）多于抑制性 LSO 神经元。较小比例的抑制性神经元具有 IC 投射（兴奋性为 45%，兴奋性为 64%），这表明抑制性 LSO 神经元可能有更多投射到其他区域，例如外侧丘系或更分布的 IC 投射。抑制性 LSO 神经元几乎完全投射同侧，占来自 LSO 的发射器类型标记的同侧 IC 投射的相当大的比例 (41%)，并表现出中等的低频偏差 (H-L 差异 10%)。三分之二的兴奋性神经元投射到对侧，并有轻微的高频偏差（4%）。三分之一的兴奋性 LSO 神经元投射到 IC 同侧，这些细胞强烈偏向 LSO 的低频肢体 (37%)。这种投射似乎是具有良好低频听力的动物的物种特异性，这表明这可能是这种能力的专门化。原位杂交用于鉴定蒙古沙鼠外侧上橄榄（LSO）的抑制性和兴奋性主要神经元。抑制性 LSO 神经元数量较少，且投射到同侧。三分之一的兴奋性神经元投射到同侧并偏向 LSO 的低频肢体。这种投影在具有良好低频听力的动物中表现出物种特异性。
Sound localization critically relies on brainstem neurons that compare information from the two ears. The conventional role of the lateral superior olive (LSO) is extraction of intensity differences; however, it is increasingly clear that relative timing, especially of transients, is also an important function. Cellular diversity within the LSO that is not well understood may underlie its multiple roles. There are glycinergic inhibitory and glutamatergic excitatory principal neurons in the LSO, however, there is some disagreement regarding their relative distribution and projection pattern. Here we employ in situ hybridization to definitively identify transmitter types combined with retrograde labeling of projections to the inferior colliculus (IC) to address these questions. Excitatory LSO neurons were more numerous (76%) than inhibitory ones. A smaller proportion of inhibitory neurons were IC-projecting (45% vs. 64% for excitatory) suggesting that inhibitory LSO neurons may have more projections to other regions such the lateral lemniscus or more distributed IC projections. Inhibitory LSO neurons almost exclusively projected ipsilaterally making up a sizeable proportion (41%) of the transmitter type-labeled ipsilateral IC projection from LSO and exhibited a moderate low frequency bias (10% difference H-L). Two thirds of excitatory neurons projected contralaterally and had a slight high frequency bias (4%). One third of excitatory LSO neurons projected ipsilaterally to the IC and these cells were strongly biased toward the low frequency limb of the LSO (37%). This projection appears to be species specific in animals with good low frequency hearing suggesting that this may be a specialization for such ability. In situ hybridization was used to identify inhibitory and excitatory principal neurons of the lateral superior olive (LSO) of Mongolian gerbil. Inhibitory LSO neurons were less numerous and projected ipsilaterally. One third of excitatory neurons projected ipsilaterally and were biased to the low-frequency limb of the LSO. This projection appears species specific in animals with good low frequency hearing.
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影响因子：
3.1
作者：
Radtke-Schuller S;Schuller G;Angenstein F;Grosser OS;Goldschmidt J;Budinger E
通讯作者：
Budinger E
影响因子：
2.5
作者：
RYAN, AF;SCHWARTZ, IR;WANG, ZX
通讯作者：
WANG, ZX
DOI：
10.1007/bf00213596
发表时间：
1992-01-01
期刊：
ANATOMY AND EMBRYOLOGY
影响因子：
--
作者：
VETTER, DE;MUGNAINI, E
通讯作者：
MUGNAINI, E
影响因子：
2.9
作者：
Ito, Tetsufumi;Oliver, Douglas L.
通讯作者：
Oliver, Douglas L.
影响因子：
2.5
作者：
HENKEL, CK;BRUNSOBECHTOLD, JK
通讯作者：
BRUNSOBECHTOLD, JK