Myocardial Injury and Overload among Amateur Marathoners as Indicated by Changes in Concentrations of Cardiovascular Biomarkers.
Myocardial Injury and Overload among Amateur Marathoners as Indicated by Changes in Concentrations of Cardiovascular Biomarkers.
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DOI：
10.3390/ijerph17176191
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发表时间：
2020-08-26
影响因子：
--
通讯作者：
Lewicka E
中科院分区：
文献类型：
--
作者：
Kaleta-Duss AM;Lewicka-Potocka Z;Dąbrowska-Kugacka A;Raczak G;Lewicka E
马拉松在业余爱好者中越来越受欢迎。然而，剧烈运动对业余爱好者心血管系统的影响尚未得到研究。分析马拉松对反映心脏损伤和超负荷的生物标志物动力学的影响可能会给这个问题带来新的见解。我们研究了跑马拉松对男性业余跑者中高敏心肌肌钙蛋白 I (hs-cTnI)、心型脂肪酸结合蛋白 (H-FABP)、N 末端心房钠尿肽 (NT-proANP)、B 型钠尿肽 (BNP)、生长分化因子 15 (GDF-15) 和半乳糖凝集素 3 (Gal-3) 浓度的影响。该研究包括 35 名业余马拉松运动员，并分为 3 个阶段：S1——马拉松赛前两周，S2——终点线处，S3——马拉松赛后两周。在每个阶段收集血样并分析生物标志物和实验室参数。所有研究的生物标志物的浓度在 S2 时均显着较高，而在 S3 时与 S1 相比没有显着差异。业余爱好者跑马拉松会导致心脏损伤和压力的生物标志物急剧上升。重复的剧烈运动是否会对业余马拉松运动员的心血管产生长期不良影响还需要进一步研究。
Marathons continue to grow in popularity among amateurs. However, the impact of intensive exercise on the amateur’s cardiovascular system has not yet been studied. Analysis of the influence of the marathon on kinetics of biomarkers reflecting cardiac injury and overload may bring new insights into this issue. We investigated the effect of running a marathon on the concentrations of high sensitivity cardiac troponin I (hs-cTnI), heart-type fatty acid binding protein (H-FABP), N-terminal proatrial natriuretic peptide (NT-proANP), B-type natriuretic peptide (BNP), growth differentiation factor 15 (GDF-15) and galectin 3 (Gal-3) in the population of male amateur runners. The study included 35 amateur marathoners and followed 3 stages: S1—two weeks prior to the marathon, S2—at the finish line and S3—two weeks after. Blood samples were collected at each stage and analyzed for biomarkers and laboratory parameters. Concentrations of all studied biomarkers were significantly higher at S2, whereas at S3 did not differ significantly compared to S1. Running a marathon by an amateur causes an acute rise in biomarkers of cardiac injury and stress. Whether repetitive bouts of intensive exercise elicit long-term adverse cardiovascular effects in amateur marathoners needs further research.
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影响因子：
4.1
作者：
Scherr, Johannes;Braun, Siegmund;Halle, Martin
通讯作者：
Halle, Martin
DOI：
10.1097/00149831-200606000-00015
发表时间：
2006-06-01
影响因子：
--
作者：
Scharhag, Juergen;Urhausen, Axel;Kindermann, Wilfried
通讯作者：
Kindermann, Wilfried
影响因子：
1.5
作者：
Dunn, Michael E.;Manfredi, Thomas G.;Colton, Heidi M.
通讯作者：
Colton, Heidi M.
影响因子：
2.8
作者：
Wilhelm, Matthias;Nuoffer, Jean-Marc;Saner, Hugo
通讯作者：
Saner, Hugo
影响因子：
8.3
作者：
Klenk, Christopher;Brunner, Horst;Schmidt-Trucksaess, Arno
通讯作者：
Schmidt-Trucksaess, Arno