Is executive dysfunction a risk marker or consequence of psychopathology? A test of executive function as a prospective predictor and outcome of general psychopathology in the adolescent brain cognitive development study®.
Is executive dysfunction a risk marker or consequence of psychopathology? A test of executive function as a prospective predictor and outcome of general psychopathology in the adolescent brain cognitive development study®.
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DOI：
10.1016/j.dcn.2021.100994
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发表时间：
2021-10
影响因子：
4.7
通讯作者：
Pizzagalli DA
中科院分区：
文献类型：
--
作者：
Romer AL;Pizzagalli DA
执行功能障碍可能是青少年精神病理学的一种跨诊断认知缺陷。较差的执行功能预示着一般精神病理学两年内的变化。更普遍的精神病理学前瞻性地预测了执行功能在两年内的变化。执行功能既是青少年跨诊断精神病的危险标志，也是其后果。普通精神病理学(‘p’)因素捕捉不同精神障碍之间的共同差异。一种假设是执行功能差(EF)对p有贡献。尽管EF与p同时相关，但尚不清楚EF是否预测p或是p的结果。我们首次在两年多的纵向研究中对9845名青春期前儿童(9-12岁)的EF和p之间的预期关系进行了研究。我们在基线以及一年和两年的随访波中确定了精神病理学的高阶因素模型。与以前的研究一致，EF和P之间出现了横截面的反相关关系。使用残差变化模型，基线EF前瞻性地预测了两年后的p因素得分，控制了之前的p、性别、年龄、种族/民族、父母教育和家庭收入。基线p因素得分也可预测两年后EF的变化。特异性测试表明，EF和P之间的双向预期关系在外化、内化、神经发育、躯体化和脱离症状中很大程度上是可以概括的。EF一致地预测外在症状和神经发育症状的变化。这些新的结果表明，执行功能障碍既是一般精神病理学的风险标志，也是其后果。EF可能是一个很有前途的跨诊断干预目标，以预防精神病理的发生和维持。
Executive dysfunction may be a transdiagnostic cognitive deficit of psychopathology in youth. Poorer executive function prospectively predicted two-year change in general psychopathology. Greater general psychopathology prospectively predicted two-year change in executive function. Executive function is both a risk marker and consequence of youth transdiagnostic psychopathology. A general psychopathology (‘p’) factor captures shared variation across mental disorders. One hypothesis is that poor executive function (EF) contributes to p. Although EF is related to p concurrently, it is unclear whether EF predicts or is a consequence of p. For the first time, we examined prospective relations between EF and p in 9845 preadolescents (aged 9–12) from the Adolescent Brain Cognitive Development Study® longitudinally over two years. We identified higher-order factor models of psychopathology at baseline and one- and two-year follow-up waves. Consistent with previous research, a cross-sectional inverse relationship between EF and p emerged. Using residualized-change models, baseline EF prospectively predicted p factor scores two years later, controlling for prior p, sex, age, race/ethnicity, parental education, and family income. Baseline p factor scores also prospectively predicted change in EF two years later. Tests of specificity revealed that bi-directional prospective relations between EF and p were largely generalizable across externalizing, internalizing, neurodevelopmental, somatization, and detachment symptoms. EF consistently predicted change in externalizing and neurodevelopmental symptoms. These novel results suggest that executive dysfunction is both a risk marker and consequence of general psychopathology. EF may be a promising transdiagnostic intervention target to prevent the onset and maintenance of psychopathology.
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影响因子：
2.6
作者：
Donati G;Meaburn E;Dumontheil I
通讯作者：
Dumontheil I
影响因子：
10.5
作者：
Cannon, Mary;Moffitt, Terrie E.;Poulton, Richie
通讯作者：
Poulton, Richie
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
DOI：
10.1097/01.chi.0000046865.56865.79
发表时间：
2003-07-01
影响因子：
13.3
作者：
Egger, HL;Costello, EJ;Angold, A
通讯作者：
Angold, A
影响因子：
25.8
作者：
Alnaes, Dag;Kaufmann, Tobias;Westlye, Lars T.
通讯作者：
Westlye, Lars T.