The impact of preexisting psychiatric disorders and antidepressant use on COVID-19 related outcomes: a multicenter study.
The impact of preexisting psychiatric disorders and antidepressant use on COVID-19 related outcomes: a multicenter study.
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DOI：
10.1038/s41380-023-02049-4
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发表时间：
2023-06
影响因子：
11
通讯作者：
Levin, Frances R. R.
中科院分区：
文献类型：
--
作者：
Schultebraucks, Katharina;Blekic, Wivine;Basaraba, Cale;Corbeil, Tom;Khan, Zain;Henry, Brandy F. F.;Krawczyk, Noa;Rivera, Bianca D. D.;Allen, Bennett;Arout, Caroline;Pincus, Harold Alan;Martinez, Diana M. M.;Levin, Frances R. R.
先前存在的精神障碍与covid -19相关的结果有关。然而，研究结果并不一致，需要对COVID-19感染严重程度、发病率和死亡率等更广泛的结果进行彻底分析。我们调查了精神诊断和/或抗抑郁药的使用是否影响COVID-19结局的严重程度。这项回顾性队列研究评估了2020年3月1日至2021年2月23日期间被诊断为COVID-19的116,498名患者的INSIGHT临床研究网络的电子健康记录。我们将住院、插管/机械通气、急性肾衰竭、严重败血症和死亡作为与covid -19相关的结局。在使用倾向评分匹配来控制人口统计学和医学合并症后，我们使用列联表来评估(1)有精神疾病史的患者是否有更严重的COVID-19相关结局的高风险，以及(2)使用抗抑郁药是否降低了更严重的COVID-19感染的风险。先前存在的精神疾病与住院风险增加以及急性肾衰竭和严重败血症等后续结果相关，包括精神分裂症谱系障碍或双相情感障碍患者死亡风险增加。抗抑郁药的使用与脓毒症（p = 0.033）和死亡（p = 0.026）的风险显著降低相关。在接受与covid -19相关的医疗服务之前进行精神障碍诊断，会增加发生更严重的covid -19相关结果以及随后的健康并发症的风险。然而，有迹象表明，使用抗抑郁药可能会降低这种风险。这可能对COVID-19患者的治疗和预后产生重大影响。
Pre-existing mental disorders are linked to COVID-19-related outcomes. However, the findings are inconsistent and a thorough analysis of a broader spectrum of outcomes such as COVID-19 infection severity, morbidity, and mortality is required. We investigated whether the presence of psychiatric diagnoses and/or the use of antidepressants influenced the severity of the outcome of COVID-19. This retrospective cohort study evaluated electronic health records from the INSIGHT Clinical Research Network in 116,498 individuals who were diagnosed with COVID-19 between March 1, 2020, and February 23, 2021. We examined hospitalization, intubation/mechanical ventilation, acute kidney failure, severe sepsis, and death as COVID-19-related outcomes. After using propensity score matching to control for demographics and medical comorbidities, we used contingency tables to assess whether patients with (1) a history of psychiatric disorders were at higher risk of more severe COVID-19-related outcomes and (2) if use of antidepressants decreased the risk of more severe COVID-19 infection. Pre-existing psychiatric disorders were associated with an increased risk for hospitalization, and subsequent outcomes such as acute kidney failure and severe sepsis, including an increased risk of death in patients with schizophrenia spectrum disorders or bipolar disorders. The use of antidepressants was associated with significantly reduced risk of sepsis (p = 0.033), death (p = 0.026). Psychiatric disorder diagnosis prior to a COVID-19-related healthcare encounter increased the risk of more severe COVID-19-related outcomes as well as subsequent health complications. However, there are indications that the use of antidepressants might decrease this risk. This may have significant implications for the treatment and prognosis of patients with COVID-19.
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DOI：
10.1159/000365542
发表时间：
2015-01-01
期刊：
COMORBIDITY OF MENTAL AND PHYSICAL DISORDERS
影响因子：
--
作者：
Mueller, Norbert
通讯作者：
Mueller, Norbert
影响因子：
7.4
作者：
通讯作者：
--
DOI：
10.1073/pnas.1531903100
发表时间：
2003-07-22
影响因子：
11.1
作者：
Kiecolt-Glaser, JK;Preacher, KJ;Glaser, R
通讯作者：
Glaser, R
影响因子：
5.4
作者：
Chen S;Fernandez-Egea E;Jones PB;Lewis JR;Cardinal RN
通讯作者：
Cardinal RN
影响因子：
6.7
作者：
Diez-Quevedo, Crisanto;Iglesias-Gonzalez, Maria;Cuevas-Esteban, Jorge
通讯作者：
Cuevas-Esteban, Jorge