The Magnetic Couples Study: protocol for a mixed methods prospective cohort study of HIV-serodifferent heterosexual couples' perspectives and use of pre-exposure prophylaxis (PrEP).
The Magnetic Couples Study: protocol for a mixed methods prospective cohort study of HIV-serodifferent heterosexual couples' perspectives and use of pre-exposure prophylaxis (PrEP).
复制标题
DOI：
10.1136/bmjopen-2021-048993
复制
发表时间：
2021-07-01
期刊：
影响因子：
2.9
通讯作者：
Anderson PL
中科院分区：
文献类型：
--
作者：
McMahon JM;Simmons J;Haberer JE;Mannheimer S;Leblanc NM;Torres L;Quiles R;Aedo G;Javier A;Braksmajer A;Harriman G;Trabold N;Pouget ER;Kurth A;Smith MDR;Brasch J;Podsiadly EJ;Anderson PL
血清不同异性伴侣之间的艾滋病毒传播在维持全球艾滋病毒流行方面发挥着关键作用。在美国，异性恋者中所有新发艾滋病毒感染者中有一半是由已婚的混合身份夫妇内传播的。口服 HIV 暴露前预防 (PrEP) 是一种非常有效的预防方法，但在血清不同的夫妇中尚未得到充分利用。此外，关于美国 HIV 血清差异夫妇的观点以及单独使用 PrEP 或与其他预防方法结合使用的研究也很缺乏。在本文中，我们描述了磁力夫妇研究的研究方案，旨在填补有关 HIV 血清不同异性夫妇对 PrEP 的观点、经验和利用的关键知识空白。磁力夫妇研究是一项混合方法前瞻性队列研究，旨在描述居住在纽约市的 HIV 血清不同异性夫妇之间的时间模式，并确定在护理连续体（PrEP 认知、联系、摄取、保留和药物依从性）中 PrEP 结果的多个层面（个人、夫妇、HCF）的决定因素。该研究还将检查 PrEP 的临床管理、副作用以及性相关和物质使用相关行为的变化。招募了 230 名已接受口服 PrEP 的混合状态夫妇的前瞻性队列，并在 18 个月内进行了季度评估；此外，还招募了 150 名目前未接受 PrEP 的混合身份夫妇作为横断面样本。对 25 对夫妇的子样本进行了深入的半结构化定性访谈。使用多级分析的参与者-合作伙伴相互依赖建模将用于纵向二元数据的分析。框架分析将用于分析定性数据。并行收敛设计将用于混合方法集成。该研究得到了罗切斯特大学机构审查委员会的批准（RSRB00052766）。研究结果将分发给社区成员和提供者以及研究人员和政策制定者。
HIV transmission within serodifferent heterosexual couples plays a key role in sustaining the global HIV pandemic. In the USA, transmission within established mixed-status couples accounts for up to half of all new HIV infections among heterosexuals. Oral HIV pre-exposure prophylaxis (PrEP) is a highly effective prevention method, although underutilised among serodifferent couples. Moreover, there is a dearth of research on US HIV-serodifferent couples’ perspectives and use of PrEP, alone or in combination with other prevention methods. In this paper, we describe the study protocol for the Magnetic Couples Study, designed to fill critical knowledge gaps regarding HIV-serodifferent heterosexual couples’ perspectives, experiences and utilisation of PrEP. The Magnetic Couples Study is a mixed methods prospective cohort study designed to describe temporal patterns and identify determinants at multiple levels (individual, couple, HCF) of PrEP outcomes along the care continuum (PrEP awareness, linkage, uptake, retention and medication adherence) among HIV-serodifferent heterosexual couples residing in New York City. The study will also examine clinical management of PrEP, side effects and changes in sexual-related and substance use–related behaviour. A prospective cohort of 230 mixed-status couples already on oral PrEP was recruited, with quarterly assessments over 18 months; in addition, a cross-sectional sample of 150 mixed-status couples not currently on PrEP was recruited. In-depth semistructured qualitative interviews were conducted with a subsample of 25 couples. Actor-partner interdependence modelling using multilevel analysis will be employed for the analysis of longitudinal dyadic data. Framework analysis will be used to analyse qualitative data. A parallel convergent design will be used for mixed methods integration. The study was approved by the University of Rochester Institutional Review Board (RSRB00052766). Study findings will be disseminated to community members and providers and to researchers and policy makers.
登录
查看更多内容
影响因子：
4.4
作者：
Liu, Chenglong;Hu, Haihong;Goparaju, Lakshmi;Plankey, Michael;Bacchetti, Peter;Weber, Kathleen;Correa, Nereida;Nowicki, Marek;Wilson, Tracey E.
通讯作者：
Wilson, Tracey E.
影响因子：
1.4
作者：
Farthing, Heather;Rodriguez, Anamaria;Doblecki-Lewis, Susanne
通讯作者：
Doblecki-Lewis, Susanne
影响因子：
168.9
作者：
Jia, Zhongwei;Mao, Yurong;Shao, Yiming
通讯作者：
Shao, Yiming
影响因子：
6.4
作者：
Hughes, James P.;Baeten, Jared M.;Celum, Connie
通讯作者：
Celum, Connie
美国国家心理健康研究所多站点EBAN HIV/STD预防措施针对非裔美国人艾滋病毒血清探索夫妇：一项群集随机试验。
影响因子：
--
作者：
El-Bassel, Nabila;Jemmott, John B.;Landis, J. Richard;Pequegnat, Willo;Wingood, Gina M.;Wyatt, Gail E.;Bellamy, Scarlett L.
通讯作者：
Bellamy, Scarlett L.