A Parametric Analysis of Capillary Height in Single-Layer, Small-Scale Microfluidic Artificial Lungs.
A Parametric Analysis of Capillary Height in Single-Layer, Small-Scale Microfluidic Artificial Lungs.
复制标题
单层小规模微流控人工肺中毛细血管高度的参数分析。
DOI：
10.3390/mi13060822
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发表时间：
2022-05-25
期刊：
影响因子：
3.4
通讯作者：
中科院分区：
文献类型：
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作者：
微流控人工肺（μALs）因其能够接近模拟天然肺的大小、尺度和细胞环境而受到人们的研究。研究人员已经开发出人工毛细管直径小（10-50 μ m，以提高气体交换效率）和毛细管直径大（~100 μ m，以简化设计和施工）的μ al。然而，目前还没有研究直接考察毛细高度对μAL性质的影响。本文利用Murray定律和Hagen-Poiseuille方程设计了毛细管高度在10 ~ 100µm之间的单层小尺度μ al。每个µAL包含两种血液通道类型：用于气体交换的毛细血管；以及为毛细血管输送血液的分配渠道。选择毛细管高度为30、60和100µm的三种设计进行进一步的建模、实施和血液测试。流动模拟用于验证和确保压力相等。设计是用软光刻技术制作的。用全牛血测试气体交换和压降。所有三种设计都表现出相似的压降和气体交换；然而，与30µm和100µm的设计相比，60µm高的μAL具有更高的壁面剪切率（尽管是生理性的），更小的启动体积和更小的总血液接触表面积。未来的μAL设计在优化性能时可能需要考虑毛细高度的影响。
Microfluidic artificial lungs (μALs) are being investigated for their ability to closely mimic the size scale and cellular environment of natural lungs. Researchers have developed μALs with small artificial capillary diameters (10–50 µm; to increase gas exchange efficiency) and with large capillary diameters (~100 µm; to simplify design and construction). However, no study has directly investigated the impact of capillary height on μAL properties. Here, we use Murray’s law and the Hagen-Poiseuille equation to design single-layer, small-scale μALs with capillary heights between 10 and 100 µm. Each µAL contained two blood channel types: capillaries for gas exchange; and distribution channels for delivering blood to/from capillaries. Three designs with capillary heights of 30, 60, and 100 µm were chosen for further modeling, implementation and testing with blood. Flow simulations were used to validate and ensure equal pressures. Designs were fabricated using soft lithography. Gas exchange and pressure drop were tested using whole bovine blood. All three designs exhibited similar pressure drops and gas exchange; however, the μAL with 60 µm tall capillaries had a significantly higher wall shear rate (although physiologic), smaller priming volume and smaller total blood contacting surface area than the 30 and 100 µm designs. Future μAL designs may need to consider the impact of capillary height when optimizing performance.
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影响因子：
9.6
作者：
Lehr, Carli J.;Zaas, David W.;Turner, David A.
通讯作者：
Turner, David A.
DOI：
10.1161/atvbaha.117.309868
发表时间：
2017-10
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Adili R;Tourdot BE;Mast K;Yeung J;Freedman JC;Green A;Luci DK;Jadhav A;Simeonov A;Maloney DJ;Holman TR;Holinstat M
通讯作者：
Holinstat M
影响因子：
2.4
作者：
Gimbel, Alla A.;Hsiao, James C.;Borenstein, Jeffrey T.
通讯作者：
Borenstein, Jeffrey T.
影响因子：
3.2
作者：
Matharoo, Harpreet;Dabaghi, Mohammadhossein;Selvaganapathy, P. Ravi
通讯作者：
Selvaganapathy, P. Ravi
影响因子：
4.9
作者：
Kovach, Kyle M.;Capadona, Jeffrey R.;Potkay, Joseph A.
通讯作者：
Potkay, Joseph A.