Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens.
Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens.
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DOI：
10.1016/j.celrep.2022.110795
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发表时间：
2022-05-10
期刊：
影响因子：
8.8
通讯作者：
Alvarez, Veronica A.
中科院分区：
文献类型：
--
作者：
Burke, Dennis A.;Alvarez, Veronica A.
伏核(NAC)回路的多巴胺调制是奖赏寻求和强化学习理论的核心。尽管经过几十年的努力，NAC微电路上的急性多巴胺作用仍然令人费解。在这里，我们剖析了多巴胺对小鼠脑片中中棘神经元(MSN)之间的侧向抑制的直接作用，并发现它们是路径特异性的。多巴胺有效地抑制突触前表达多巴胺D2受体的MSN(D2-MSN)的GABA能传递，而增强突触前表达多巴胺D2受体的MSN(D1-MSN)向其他D1-MSN的GABA能传递。令我们惊讶的是，突触前D2受体只介导了内源性和外源性多巴胺引起的抑郁的一半。突触前5-HT1B受体是多巴胺诱导的突触抑制的重要组成部分。本研究通过D2和5-HT1B受体参与D2-MSN突触的多巴胺抑制，阐明了NAc中多巴胺作用的机制。Burke和Alvarez发现，在伏隔核，多巴胺抑制或加强投射神经元之间的侧向抑制，这取决于所分离的特定突触。多巴胺对D2-MSN GABA传递的抑制涉及5-HT1B受体的激活，提示单胺和受体之间的串扰在伏隔神经回路功能中发挥作用。
Dopamine modulation of nucleus accumbens (NAc) circuitry is central to theories of reward seeking and reinforcement learning. Despite decades of effort, the acute dopamine actions on the NAc microcircuitry remain puzzling. Here, we dissect out the direct actions of dopamine on lateral inhibition between medium spiny neurons (MSNs) in mouse brain slices and find that they are pathway specific. Dopamine potently depresses GABAergic transmission from presynaptic dopamine D2 receptor-expressing MSNs (D2-MSNs), whereas it potentiates transmission from presynaptic dopamine D1 receptor-expressing MSNs (D1-MSNs) onto other D1-MSNs. To our surprise, presynaptic D2 receptors mediate only half of the depression induced by endogenous and exogenous dopamine. Presynaptic serotonin 5-HT1B receptors are responsible for a significant component of dopamine-induced synaptic depression. This study clarifies the mechanistic understanding of dopamine actions in the NAc by showing pathway-specific modulation of lateral inhibition and involvement of D2 and 5-HT1B receptors in dopamine depression of D2-MSN synapses. Burke and Alvarez find that, in the nucleus accumbens, dopamine depresses or potentiates lateral inhibition between projection neurons, depending on the specific synapses isolated. Dopamine depression of D2-MSN GABA transmission involves activation of 5-HT1B receptors, suggesting that cross-talk between monoamines and receptors plays a role in accumbens circuit function.
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影响因子：
16.2
作者：
Corkrum, Michelle;Covelo, Ana;Araque, Alfonso
通讯作者：
Araque, Alfonso
伏隔核中GABA能中型棘神经元的分布和分室组织。
影响因子：
3.5
作者：
Gangarossa G;Espallergues J;de Kerchove d'Exaerde A;El Mestikawy S;Gerfen CR;Hervé D;Girault JA;Valjent E
通讯作者：
Valjent E
DOI：
10.1523/jneurosci.3952-07.2008
发表时间：
2008-07-09
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Gerfen CR;Paletzki R;Worley P
通讯作者：
Worley P
影响因子：
3.6
作者：
Nair, Sunila G.;Furay, Amy R.;Liu, Yusha;Neumaier, John F.
通讯作者：
Neumaier, John F.
影响因子：
5.3
作者：
Adrover, Martin F.;Shin, Jung Hoon;Alvarez, Veronica A.
通讯作者：
Alvarez, Veronica A.