Association of cardiorespiratory fitness with left ventricular remodeling and diastolic function: the Cooper Center Longitudinal Study.
Association of cardiorespiratory fitness with left ventricular remodeling and diastolic function: the Cooper Center Longitudinal Study.
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DOI：
10.1016/j.jchf.2014.01.004
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发表时间：
2014-06
期刊：
影响因子：
--
通讯作者：
Berry JD
中科院分区：
文献类型：
--
作者：
Brinker SK;Pandey A;Ayers CR;Barlow CE;DeFina LF;Willis BL;Radford NB;Farzaneh-Far R;de Lemos JA;Drazner MH;Berry JD
比较心肺适能与心脏结构和功能超声心动图测量之间的横截面相关性。呼吸适应性（适应性）与心力衰竭风险呈负相关。然而，健身降低心力衰竭风险的机制尚未完全了解。我们纳入了来自库珀中心纵向研究的1,678名男性和1,247名女性，他们在1999-2011年期间接受了超声心动图检查。健康状况通过Balke方案测量，并分类为特定年龄的四分位数，四分位数1代表低健康状况。采用多变量线性回归分析确定健康（MET）与相对室壁厚度（RWT）、左心室舒张末期内径与体表面积指数（LVEDD/BSA）、左心房容积与体表面积指数（LA/BSA）、左心室收缩功能（LVEF）和E/e′比值之间的横断面相关性。较高的中年健康水平（MET）与较大的左心房容积指数（男性：β = 0.769，p <0.0001;女性：β = 0.879，p值= <0.0001）和LVEDD指数（男性：β = 0.231，p <0.001;女性：β = 0.264，p <0.0001）相关。同样，较高的健康水平与较小的RWT（男性：β = -0.002; p = 0.04;女性：β =-0.005，p <0.0001）和E/e′比（男性：β = -0.11; p = 0.003;女性：β =-0.13，p值= 0.01）相关。然而，低体能与LVEF之间无相关性（P=NS）。低适应性与向心性重构和舒张功能障碍的患病率较高相关，这表明运动可能通过其对有利的心脏重构和改善舒张功能的影响来降低心力衰竭风险。
To compare the cross-sectional associations between cardiorespiratory fitness and echocardiographic measures of cardiac structure and function. Cardiorespiratory fitness (fitness) is inversely associated with heart failure risk. However, the mechanism through which fitness lowers heart failure risk is not fully understood. We included 1,678 men and 1,247 women from the Cooper Center Longitudinal Study who received an echocardiogram from 1999—2011. Fitness was measured by Balke protocol and categorized into age-specific quartiles with quartile 1 representing low fitness. Cross sectional associations between fitness (in METs) and relative wall thickness (RWT), left ventricular end-diastolic diameter indexed to body surface area (LVEDD/BSA), left atrial volume indexed to body surface area (LA Vol/BSA), left ventricular systolic function (LVEF), and E/e′ ratio were determined using multivariable linear regression analysis. Higher levels of mid life fitness (METs) was associated with larger indexed LA volume (Men: β = 0.769, p <0.0001; Women: β = 0.879, p value = <0.0001) and indexed LVEDD (Men: β = 0.231, p <0.001; Women: β = 0.264, p <0.0001). Similarly, a higher level of fitness was associated with a smaller RWT (Men: β = -0.002; p = 0.04; Women: β = -0.005, p <0.0001) and E/e′ ratio (Men: β = -0.11; p = 0.003; Women: β = -0.13, p value = 0.01). However, there was no association between low fitness and LVEF (P=NS). Low fitness is associated with a higher prevalence of concentric remodeling and diastolic dysfunction, suggesting that exercise may lower heart failure risk through its effect on favorable cardiac remodeling and improved diastolic function.
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DOI：
10.1161/circheartfailure.110.958785
发表时间：
2010-11
期刊：
Circulation. Heart failure
影响因子：
--
作者：
Kitzman DW;Brubaker PH;Morgan TM;Stewart KP;Little WC
通讯作者：
Little WC
影响因子：
24
作者：
Lester, Steven J.;Tajik, A. Jamil;Oh, Jae K.
通讯作者：
Oh, Jae K.
影响因子：
8.3
作者：
Lam, Carolyn S. P.;Grewal, Jasmine;Pellikka, Patricia A.
通讯作者：
Pellikka, Patricia A.
DOI：
10.1161/circimaging.110.959403
发表时间：
2011-01
期刊：
Circulation. Cardiovascular imaging
影响因子：
--
作者：
Jain A;McClelland RL;Polak JF;Shea S;Burke GL;Bild DE;Watson KE;Budoff MJ;Liu K;Post WS;Folsom AR;Lima JA;Bluemke DA
通讯作者：
Bluemke DA
影响因子：
20.1
作者：
Koch LG;Kemi OJ;Qi N;Leng SX;Bijma P;Gilligan LJ;Wilkinson JE;Wisløff H;Høydal MA;Rolim N;Abadir PM;van Grevenhof EM;Smith GL;Burant CF;Ellingsen O;Britton SL;Wisløff U
通讯作者：
Wisløff U