Histones: The critical players in innate immunity.
Histones: The critical players in innate immunity.
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组蛋白：先天免疫的关键参与者
DOI：
10.3389/fimmu.2022.1030610
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
不同物种中高度保守的组蛋白似乎代表了生物界中一种非常古老和普遍的宿主对微生物的先天防御系统。组蛋白是核物质的重要组成部分，并作为DNA转录的控制开关。然而，组蛋白也存在于细胞质、细胞膜和细胞外液中，在那里它们起宿主防御作用并促进炎症反应。在某些情况下，细胞外组蛋白可以充当损伤相关分子模式（DAMP）并结合模式识别受体（PRR），从而触发先天免疫应答并引起初始器官损伤。组蛋白及其片段作为抗菌肽（AMP）在体内外直接清除细菌、病毒、真菌和寄生虫。组蛋白还作为中性粒细胞细胞外陷阱（NET）、中性粒细胞激活剂和纤溶酶原受体的成分参与吞噬细胞相关的先天免疫反应。此外，组蛋白修饰作为表观遗传调控的重要组成部分，在天然免疫应答和相应防御基因的表达调控中发挥着至关重要的作用。在此，我们综述了组蛋白在先天免疫反应中的调节作用，这为抗生素的开发以及将组蛋白用作炎症性疾病、败血症、自身免疫性疾病和COVID-19的治疗靶点提供了新的策略。
The highly conserved histones in different species seem to represent a very ancient and universal innate host defense system against microorganisms in the biological world. Histones are the essential part of nuclear matter and act as a control switch for DNA transcription. However, histones are also found in the cytoplasm, cell membranes, and extracellular fluid, where they function as host defenses and promote inflammatory responses. In some cases, extracellular histones can act as damage-associated molecular patterns (DAMPs) and bind to pattern recognition receptors (PRRs), thereby triggering innate immune responses and causing initial organ damage. Histones and their fragments serve as antimicrobial peptides (AMPs) to directly eliminate bacteria, viruses, fungi, and parasites in vitro and in vivo. Histones are also involved in phagocytes-related innate immune response as components of neutrophil extracellular traps (NETs), neutrophil activators, and plasminogen receptors. In addition, as a considerable part of epigenetic regulation, histone modifications play a vital role in regulating the innate immune response and expression of corresponding defense genes. Here, we review the regulatory role of histones in innate immune response, which provides a new strategy for the development of antibiotics and the use of histones as therapeutic targets for inflammatory diseases, sepsis, autoimmune diseases, and COVID-19.
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影响因子：
5.6
作者：
通讯作者：
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影响因子：
6
作者：
Conceição-Silva F;Reis CSM;De Luca PM;Leite-Silva J;Santiago MA;Morrot A;Morgado FN
通讯作者：
Morgado FN
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2.8
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通讯作者：
Rosamma, Philip
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通讯作者：
Chaby, R
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6.1
作者：
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通讯作者：
Bhatnagar, Deepak