The Immune System Throws Its Traps: Cells and Their Extracellular Traps in Disease and Protection.
The Immune System Throws Its Traps: Cells and Their Extracellular Traps in Disease and Protection.
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DOI：
10.3390/cells10081891
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发表时间：
2021-07-26
期刊：
影响因子：
6
通讯作者：
Morgado FN
中科院分区：
文献类型：
--
作者：
Conceição-Silva F;Reis CSM;De Luca PM;Leite-Silva J;Santiago MA;Morrot A;Morgado FN
2004年，首次正式描述了含有DNA的细胞外陷阱（Extracellular traps，ETP）在中性粒细胞中的杀微生物活性。从那时起，已经在参与先天性和适应性免疫应答的不同细胞群体中鉴定出了抗病毒抗体。大部分知识来自体外或离体研究;然而，在实验模型和人体生物材料中进行的体内评价证实了所获得的一些结果。有两种类型的细胞分裂被描述为自杀性的和生命性的分裂，伴随或不伴随生产细胞的死亡。研究表明，相同的细胞类型可能有一种以上的细胞形成机制，不同的细胞可能有相似的细胞形成机制。它可以通过控制或促进参与各种感染性和非感染性疾病的发展和演变的机制来起作用，所述疾病例如自身免疫性疾病、心血管疾病、血栓性疾病和肿瘤性疾病等。本文综述了嗜中性粒细胞、巨噬细胞、肥大细胞、嗜酸性粒细胞、嗜碱性粒细胞、浆细胞样树突状细胞中存在的CD 4+，以及B淋巴细胞、CD 4 + T淋巴细胞和CD 8 + T淋巴细胞中存在CD 4+的最新证据。此外，由于最近收集的资料，本报告亦讨论了疫情对COVID-19的影响。
The first formal description of the microbicidal activity of extracellular traps (ETs) containing DNA occurred in neutrophils in 2004. Since then, ETs have been identified in different populations of cells involved in both innate and adaptive immune responses. Much of the knowledge has been obtained from in vitro or ex vivo studies; however, in vivo evaluations in experimental models and human biological materials have corroborated some of the results obtained. Two types of ETs have been described—suicidal and vital ETs, with or without the death of the producer cell. The studies showed that the same cell type may have more than one ETs formation mechanism and that different cells may have similar ETs formation mechanisms. ETs can act by controlling or promoting the mechanisms involved in the development and evolution of various infectious and non-infectious diseases, such as autoimmune, cardiovascular, thrombotic, and neoplastic diseases, among others. This review discusses the presence of ETs in neutrophils, macrophages, mast cells, eosinophils, basophils, plasmacytoid dendritic cells, and recent evidence of the presence of ETs in B lymphocytes, CD4+ T lymphocytes, and CD8+ T lymphocytes. Moreover, due to recently collected information, the effect of ETs on COVID-19 is also discussed.
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影响因子：
4.6
作者：
Arcanjo A;Logullo J;Menezes CCB;de Souza Carvalho Giangiarulo TC;Dos Reis MC;de Castro GMM;da Silva Fontes Y;Todeschini AR;Freire-de-Lima L;Decoté-Ricardo D;Ferreira-Pereira A;Freire-de-Lima CG;Barroso SPC;Takiya C;Conceição-Silva F;Savino W;Morrot A
通讯作者：
Morrot A
影响因子：
6.7
作者：
Bruns S;Kniemeyer O;Hasenberg M;Aimanianda V;Nietzsche S;Thywissen A;Jeron A;Latgé JP;Brakhage AA;Gunzer M
通讯作者：
Gunzer M
影响因子：
2.8
作者：
Campillo-Navarro, Marcia;Leyva-Paredes, Kahiry;Chacon-Salinas, Rommel
通讯作者：
Chacon-Salinas, Rommel
影响因子：
5.7
作者：
Chen Z;Zhang H;Qu M;Nan K;Cao H;Cata JP;Chen W;Miao C
通讯作者：
Miao C
影响因子：
12.8
作者：
Choi Y;Le Pham D;Lee DH;Lee SH;Kim SH;Park HS
通讯作者：
Park HS