Motor threshold in transcranial magnetic stimulation: the impact of white matter fiber orientation and skull-to-cortex distance.
Motor threshold in transcranial magnetic stimulation: the impact of white matter fiber orientation and skull-to-cortex distance.
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DOI：
10.1002/hbm.20649
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发表时间：
2009-07
影响因子：
4.8
通讯作者：
Nahas, Ziad
中科院分区：
文献类型：
--
作者：
Herbsman, Tal;Forster, Lauren;Molnar, Christine;Dougherty, Robert;Christie, Doug;Koola, Jejo;Ramsey, Dave;Morgan, Paul S.;Bohning, Daryl E.;George, Mark S.;Nahas, Ziad
经颅磁刺激（TMS）对运动皮层的电生理机制尚不清楚。在这项研究中，我们研究了17名精神分裂症患者和非精神分裂症患者的皮质脊髓束的几个结构参数及其与TMS运动阈值（MT）的关系。我们获得了结构和扩散张量MRI扫描，并测量了皮质脊髓束感兴趣区域的分数各向异性和主要扩散方向。我们还测量了左运动区颅骨到皮层的距离。皮质脊髓束主要扩散方向的前后轨迹和颅皮质距离均与MT高度相关，而分数各向异性、年龄和精神分裂症状态与MT无关。在线性回归模型中，两个参数——头骨到皮层的距离和皮质脊髓束通过内囊时主要扩散方向的前侧分量——对MT有很高的预测作用，在MT测量中，这两个参数占观察到的方差的82% （R2 = 0.82, F = 20.27, P < 0.0001）。仅皮质脊髓束的前后方向就占解释方差的13%。
The electrophysiology of transcranial magnetic stimulation (TMS) of motor cortex is not well understood. In this study, we investigate several structural parameters of the corticospinal tract and their relation to the TMS motor threshold (MT) in 17 subjects, with and without schizophrenia. We obtained structural and diffusion tensor MRI scans and measured the fractional anisotropy and principal diffusion direction for regions of interest in the corticospinal tract. We also measured the skull-to-cortex distance over the left motor region. The anterior–posterior trajectory of principle diffusion direction of the corticospinal tract and skull-to-cortex distance were both found to be highly correlated with MT, while fractional anisotropy, age and schizophrenia status were not. Two parameters—skull-to-cortex distance and the anterior component of the principle diffusion direction of the corticospinal tract as it passes the internal capsule—are highly predictive of MT in a linear regression model, and account for 82% of the variance observed (R2 = 0.82, F = 20.27, P < 0.0001) in measurements of MT. The corticospinal tract’s anterior–posterior direction alone contributes 13% of the variance explained.
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影响因子：
5.5
作者：
MACCABEE, PJ;AMASSIAN, VE;CRACCO, RQ
通讯作者：
CRACCO, RQ
影响因子：
2.5
作者：
Mishory, A;Molnar, C;George, MS
通讯作者：
George, MS
DOI：
10.1016/0168-5597(94)90045-0
发表时间：
1994-06-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
PASCUALLEONE, A;COHEN, LG;HALLETT, M
通讯作者：
HALLETT, M
影响因子：
2.5
作者：
Chen, R;Yung, D;Li, JY
通讯作者：
Li, JY
DOI：
10.1016/s0921-884x(96)96021-x
发表时间：
1996-12-01
期刊：
ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
Kaneko, K;Kawai, S;Ofuji, A
通讯作者：
Ofuji, A