Incomplete circle of Willis variants and stroke outcome.
Incomplete circle of Willis variants and stroke outcome.
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DOI：
10.1016/j.ejrad.2022.110383
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发表时间：
2022-08
影响因子：
3.3
通讯作者：
Glodzik, Lidia
中科院分区：
文献类型：
--
作者：
Lin, Eaton;Kamel, Hooman;Gupta, Ajay;RoyChoudhury, Arindam;Girgis, Peter;Glodzik, Lidia
在一般人群中，Willis环形态存在相当大的差异，这些差异与动脉瘤、脑缺血和其他临床事件的风险相关。探讨Willis环变异与脑卒中预后的关系。我们进行了一项回顾性研究，涉及297例来自我们机构急性卒中学术注册的患者。所有患者在入院时均接受了急性卒中的头部MRA检查。审查所有影像学检查，以评估Willis环变异（特别是A1和P1发育不全或发育不全）沿着椎动脉发育不全或发育不全。卒中结局定义为良好（出院时独立行走）或不良（出院时无法行走、出院时需要辅助行走或死亡）。使用美国国立卫生研究院卒中量表评估卒中的严重程度。在34%的受试者中观察到不完整的Willis环。年龄、性别、高血压或动脉狭窄与Willis环完整性之间无显著相关性。使用logistic回归分析，我们发现，在调整入院时的年龄和卒中严重程度后，存在不完整的Willis环使卒中患者获得良好结局的几率降低了47%（p=0.046，OR 0.53，95%CI 0.281- 0.988）。这项研究表明，不完整的Willis环可能与中风患者预后较差有关。
There is considerable variation in circle of Willis morphology among the general population, and these variations have been correlated with risk of aneurysms, cerebral ischemia, and other clinical events. To investigate the relationship between circle of Willis variants and stroke outcome. We performed a retrospective study involving 297 patients from our institution’s acute stroke academic registry. All received MRA examinations of the head upon admission for acute strokes. All imaging was reviewed to assess for circle of Willis variants (particularly A1 and P1 aplasia or hypoplasia) along with vertebral artery aplasia or hypoplasia. Stroke outcome was defined as good (walking independently at the time of discharge) or poor (inability to walk at discharge, assistance needed to walk at discharge, or death). Severity of stroke was assessed using the National Institute of Health Stroke Scale. An incomplete circle of Willis was seen in 34% of subjects. There was no significant association between age, gender, hypertension, or presence of arterial stenosis and circle of Willis completeness. Using logistic regression, we found that the presence of an incomplete circle of Willis decreased the odds of a stroke patient having a good outcome by 47% (p=0.046, OR 0.53, 95% CI 0.281– 0.988), after adjusting for age and severity of stroke at admission. This study suggests that an incomplete circle of Willis may be associated with a poorer prognosis for stroke patients.
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影响因子：
8.3
作者：
KAYEMBE, KNT;SASAHARA, M;HAZAMA, F
通讯作者：
HAZAMA, F
影响因子：
2.4
作者：
Chuang, Yu-Ming;Huang, Kuo-Lun;Lee, Tsong-Hai
通讯作者：
Lee, Tsong-Hai
影响因子：
6
作者：
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通讯作者：
La Spina, Paolino
DOI：
10.1001/archneurpsyc.1959.02340160007002
发表时间：
1959-01-01
影响因子：
--
作者：
ALPERS, BJ;BERRY, RG;PADDISON, RM
通讯作者：
PADDISON, RM
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影响因子：
2.6
作者：
Eftekhar B;Dadmehr M;Ansari S;Ghodsi M;Nazparvar B;Ketabchi E
通讯作者：
Ketabchi E