Higher incidence of pediatric anaphylaxis in northern areas of the United States.
Higher incidence of pediatric anaphylaxis in northern areas of the United States.
复制标题
美国北部地区儿童过敏反应的发生率较高。
DOI：
10.1016/j.jaci.2009.06.044
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Phipatanakul,Wanda
中科院分区：
文献类型：
--
作者：
Sheehan,WilliamJ;Graham,Dionne;Ma,Lin;Baxi,Sachin;Phipatanakul,Wanda
过敏反应是一种严重的过敏反应，病程迅速，可导致死亡。1与其他过敏性疾病相似，过敏反应的发生率在过去几十年中有所增加。2-4最近的估计表明，终生患病率为0.05%至2.0%，5食物过敏是最常见的原因。2，6一种方法是通过分析肾上腺素的药物分配数据来间接估计过敏反应的发生率。7 Camargo等人8使用这种方法证明EpiPen（Dey LP，Napa，Calif）处方的南北梯度，在北方州发现的比率最高。我们的研究仔细检查了儿童过敏反应的发生率，特别关注南北比较。为了做到这一点，我们分析了美国儿科医院的大型国家账单数据库中所有被列为过敏反应的患者。本研究的数据来自儿科健康信息系统，这是一个行政数据库，包含美国儿童健康公司下属的一组三级护理儿科医院的行政和账单数据（肖尼使命，堪萨斯州），一个儿童医院的商业联盟。我们纳入了2003年1月至2007年12月5年期间提供完整数据的所有儿科医院，包括急诊科就诊、住院和观察室停留。在整个研究期间，美国18个州的24家儿科医院提供了完整的数据。这些医院在地理上被划分在北纬39度线上，大致从华盛顿，DC延伸到加州的萨克拉门托（见本文在线知识库中的图E1）。jacionline。org）。根据美国地质学会（www.美国地质勘探局。gov），纬度大于39 N的城市被认为是北方城市（n= 11），39 N以南的城市被认为是南方城市（n= 13）。
Anaphylaxis is a severe allergic reaction that has a rapid course and can result in death. 1 Similar to other allergic diseases, the incidence of anaphylaxis has increased over the past few decades. 2-4 Recent estimates suggest a lifetime prevalence of 0.05% to 2.0%, 5 with food allergy being the most common cause. 2, 6 One approach was to indirectly estimate the incidence of anaphylaxis by analyzing medication-dispensing data for epinephrine. 7 Camargo et al8 used this method to demonstrate a north-south gradient of EpiPen (Dey LP, Napa, Calif) prescriptions, with the highest rates found in northern states. Our study scrutinized the incidence of pediatric anaphylaxis with a specific focus on a north-south comparison. To do this, we analyzed a large national billing database of US pediatric hospitals for all patient encounters billed as anaphylaxis.Data for this study were obtained from the Pediatric Health Information System, an administrative database that contains administrative and billing data from a group of tertiary care pediatric hospitals in the United States that are affiliated with the Child Health Corporation of America (Shawnee Mission, Kan), a business alliance of children’s hospitals. We included all pediatric hospitals that contributed complete data from emergency department visits, inpatient admissions, and observation unit stays during a 5-year period from January 2003 to December 2007. There were 24 pediatric hospitals in 18 states across the United States that provided complete data during the entire study period. These hospitals were divided geographically at the line of 39 N latitude, extending roughly from Washington, DC, to Sacramento, California (see Fig E1 in this article’s Online Repository at www. jacionline. org). As determined by the US Geological Society (www. usgs. gov), cities with a degree of latitude greater than 39 N were considered northern cities (n= 11), and cities south of 39 N were considered southern cities (n= 13).
影响因子：
14.2
作者：
Yocum, MW;Butterfield, JH;Silverstein, MD
通讯作者：
Silverstein, MD
影响因子：
7.1
作者：
Camargo, Carlos A., Jr.;Rifas-Shiman, Sheryl L.;Gillman, Matthew W.
通讯作者：
Gillman, Matthew W.