Stem cells as delivery vehicles for oncolytic adenoviral virotherapy.
Stem cells as delivery vehicles for oncolytic adenoviral virotherapy.
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DOI：
10.2174/156652309789753347
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发表时间：
2009-10
影响因子：
3.6
通讯作者：
Lesniak MS
中科院分区：
文献类型：
--
作者：
Kranzler J;Tyler MA;Sonabend AM;Ulasov IV;Lesniak MS
多形性胶质母细胞瘤是人类最常见的原发性颅内肿瘤。尽管癌症治疗不断取得进展，但诊断患有这种疾病的患者的结果仍然暗淡。涉及使用条件复制腺病毒（CRAd）靶向恶性脑肿瘤的新型治疗方法已经经历了广泛的研究，并被证明是胶质母细胞瘤治疗的有前途的模式。CRAd被遗传操纵以在肿瘤细胞内复制，表现出高度的感染性、细胞毒性和转基因表达。虽然在临床前试验中，各种CRAd的使用被认为是安全的颅内注射，但在患者中尚未观察到显著的治疗效果。该缺点源于与病毒裂解剂的局部递送有关的分布限制。为了增强这种治疗方式，干细胞已被探索作为病毒治疗应用中的细胞载体，因为它们具有恶性脑肿瘤的内在向性。干细胞负载的CRAd递送提供了一种更特异和有效的靶向播散性肿瘤细胞的方法，并形成了本综述的基础。
Glioblastoma multiforme is the most common primary intracranial tumor in humans. Despite continued advances in cancer therapy, the outcome for patients diagnosed with this disease remains bleak. Novel treatments involving the use of conditionally replicating adenoviruses (CRAds) to target malignant brain tumors have undergone extensive research and proven to be a promising mode of glioblastoma therapy. CRAds are genetically manipulated to replicate within tumor cells, exhibiting a high degree of infectivity, cytotoxicity, and transgene expression. While the use of various CRAds has been deemed safe for intracranial injection in preclinical trials, a significant therapeutic effect has yet to be seen in patients. This shortcoming stems from the distribution limitations involved with local delivery of virolytic agents. To enhance this modality of treatment, stem cells have been explored as cellular vehicles in virotherapy applications, given that they possess an intrinsic tropism for malignant brain tumors. Stem cell loaded CRAd delivery offers a more specific and effective method of targeting disseminated tumor cells and forms the basis for this review.
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影响因子：
158.5
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