Correspondence of executive function related functional and anatomical alterations in aging brain.
Correspondence of executive function related functional and anatomical alterations in aging brain.
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DOI：
10.1016/j.pnpbp.2013.09.001
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发表时间：
2014-01-03
影响因子：
5.6
通讯作者：
Biswal, Bharat B.
中科院分区：
文献类型：
--
作者：
Di, Xin;Rypma, Bart;Biswal, Bharat B.
神经认知衰老研究主要关注神经活动或神经结构与年龄相关的变化，但很少有研究关注两者之间的关系。本研究使用激活似然估计 (ALE) 定量回顾了 24 项关于广泛执行功能任务中 fMRI 激活与年龄相关变化的研究，以及 22 项使用基于体素形态测量 (VBM) 的关于灰质年龄相关变化的独立研究。构建了功能和结构改变图之间的联合分析。仅在背外侧前额叶皮层（DLPFC）灰质减少和功能过度激活的结合中观察到重叠，但在低激活中未观察到重叠。灰质和激活之间的联系与任务表现的相关性并不明显。讨论了这些结果的理论意义。
Neurocognitive aging studies have focused on age-related changes in neural activity or neural structure but few studies have focused on relationships between the two. The present study quantitatively reviewed 24 studies of age-related changes in fMRI activation across a broad spectrum of executive function tasks using activation likelihood estimation (ALE) and 22 separate studies of age-related changes in gray matter using voxel-based morphometry (VBM). Conjunction analyses between functional and structural alteration maps were constructed. Overlaps were only observed in the conjunction of dorsalateral prefrontal cortex (DLPFC) gray matter reduction and functional hyperactivation but not hypoactivation. It was not evident that the conjunctions between gray matter and activation were related to task performance. Theoretical implications of these results are discussed.
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影响因子：
4.8
作者：
Del Percio, Claudio;Babiloni, Claudio;Eusebi, Fabrizio
通讯作者：
Eusebi, Fabrizio
影响因子：
4.8
作者：
Eickhoff, Simon B.;Laird, Angela R.;Grefkes, Christian;Wang, Ling E.;Zilles, Karl;Fox, Peter T.
通讯作者：
Fox, Peter T.
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1093/cercor/bhp284
发表时间：
2010-09
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Biswal BB;Eldreth DA;Motes MA;Rypma B
通讯作者：
Rypma B
影响因子：
3.7
作者：
Baltes, PB;Lindenberger, U
通讯作者：
Lindenberger, U