Magnetic resonance imaging abnormalities in lenticular nuclei and cerebral cortex in schizophrenia.
Magnetic resonance imaging abnormalities in lenticular nuclei and cerebral cortex in schizophrenia.
复制标题
精神分裂症中晶状体核和大脑皮层的磁共振成像异常。
作者：
Terry L. Jernigan;Sidney Zisook;Robert K. Heaton;John T. Moranville;J. Hesselink;D. Braff
神经病理学和脑成像研究已经提供了精神分裂症患者大脑异常的证据，这些异常通常发生在大脑边缘叶内，也较少发生在基底神经节内。在本研究中，我们使用磁共振成像形态测量技术来估计精神分裂症患者和年龄和性别匹配的正常对照的特定大脑结构的体积。精神分裂症患者的内侧颞叶结构的体积估计值减少，而豆状核的体积估计值增加。还有证据表明一些精神分裂症患者的颅骨体积缩小。晶状体异常的程度（而非颞叶异常）与首次接触精神病时的年龄有关。较早发病与较大的晶状体核有关。讨论了这些结果与精神分裂症发病机制的神经发育假说的可能相关性。
Neuropathologic and brain imaging studies have produced evidence of brain abnormalities in schizophrenic patients, often within the cerebrum's limbic lobe, and, less frequently, within basal ganglia. In the present study we used magnetic resonance imaging morphometric techniques to estimate volumes of specific cerebral structures in schizophrenic patients and age- and sex-matched normal controls. Estimates of the volume of mesial temporal lobe structures were reduced and estimates of the volume of the lenticular nucleus were increased in the schizophrenic patients. There was also evidence of reduced cranial volume in some schizophrenics. The magnitude of the lenticular abnormality, but not the temporal lobe abnormality, was associated with age at first psychiatric contact; earlier onset was associated with larger lenticular nuclei. The possible relevance of these results to neurodevelopmental hypotheses about the pathogenesis of schizophrenia is discussed.
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影响因子：
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作者：
D. Braff;M. Geyer
通讯作者：
D. Braff;M. Geyer
精神分裂症额叶系统的结构异常。
影响因子：
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作者：
Andreasen,N;Nasrallah,HA;Dunn,V;Olson,SC;Grove,WM;Ehrhardt,JC;Coffman,JA;Crossett,JH
通讯作者：
Crossett,JH
影响因子：
14.5
作者：
JERNIGAN, TL;TRAUNER, DA;TALLAL, PA
通讯作者：
TALLAL, PA
精神分裂症中海马锥体细胞的方向。
影响因子：
--
作者：
Altshuler,LL;Conrad,A;Kovelman,JA;Scheibel,A
通讯作者：
Scheibel,A
影响因子：
--
作者：
Terry L. Jernigan;G. Press;J. Hesselink
通讯作者：
Terry L. Jernigan;G. Press;J. Hesselink