Identification of the molecular mechanism by which TLR ligation and IFN-gamma synergize to induce MIG.
Identification of the molecular mechanism by which TLR ligation and IFN-gamma synergize to induce MIG.
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鉴定 TLR 连接和 IFN-γ 协同诱导 MIG 的分子机制。
DOI：
10.1080/10446670410001670535
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发表时间：
2004
影响因子：
--
通讯作者：
Horton,MaureenR
中科院分区：
文献类型：
--
作者：
Powell,JonathanD;Boodoo,Sada;Horton,MaureenR
Monokine Induced by Interferon‐ (MIG), a CXC chemokine, is a potent inducer of T‐cell chemotaxis and activation and has been implicated in the host response to viral infections and tumor immunity as well as in the pathogenesis of autoimmunity and transplant rejection. Although it is known that the Toll‐Like Receptor‐4 (TLR‐4) ligand LPS synergizes with IFN‐γ to induce MIG expression in macrophages, the molecular mechanisms responsible for the synergy have yet to be elucidated. We determined that the marked synergy between LPS and IFN‐γ on MIG mRNA expression in mouse macrophages is a result of LPS‐induced NF‐κB and IFN‐γ‐induced STAT. The synergy was not dependent on new protein synthesis, was independent of TNF‐α, and occurred at the level of gene transcription. We identified 2 NF‐κB sites located at ‐154 and ‐129 of the MIG promoter proximal to the ‐responsive element that mediated this effect. Finally, we demonstrated that other TLR ligands (zymosan, double stranded RNA and CpG) synergized with IFN‐γ to induce MIG in an NF‐κB dependent fashion. These data emphasize the ability of bacterial and viral products to activate/modify immune responses and promote adaptive T cell immunity through the NF‐κB pathway.
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影响因子：
5.3
作者：
M. Morange;A. Diu;O. Bensaude;C. Babinet
通讯作者：
M. Morange;A. Diu;O. Bensaude;C. Babinet
影响因子：
7.8
作者：
Grinnell, F
通讯作者：
Grinnell, F
影响因子：
3
作者：
T. M. Hassell;E. Stanek
通讯作者：
T. M. Hassell;E. Stanek
DOI：
10.1016/s0174-173x(87)80036-5
发表时间：
1987-09
期刊：
Collagen and related research
影响因子：
--
作者：
C. W. Prince;W. T. Butler
通讯作者：
C. W. Prince;W. T. Butler
HeLa 细胞中单次热剂量产生的瞬时耐热生存反应。
影响因子：
11.2
作者：
E. Gerner;R. Boone;W. G. Connor;J. Hicks;M. Boone
通讯作者：
M. Boone