Systematic evaluation of laryngeal impairment in Sjögren's syndrome.
Systematic evaluation of laryngeal impairment in Sjögren's syndrome.
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DOI：
10.1007/s00405-021-06746-0
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Hofauer B
中科院分区：
文献类型：
--
作者：
Graf S;Kirschstein L;Knopf A;Mansour N;Jeleff-Wölfler O;Buchberger AMS;Hofauer B
干燥综合征（SjS）导致唾液腺和泪腺功能障碍。因此，患者患有口干症和干燥性角结膜炎。这可能会进一步影响声音和吞咽功能，导致生活质量受损。本研究的目的是系统评价SjS患者声音和吞咽相关生活质量的影响。根据美国-欧洲共识组（AECG）标准对SjS患者进行分类;检测Ro（SS-A）或La（SS-B）抗原抗体，完成ESSPRI。我们使用了以下生活质量问卷：EORTC QLQ H&N 35、安德森吞咽困难量表（ADI）和语音障碍指数（VHI）。患者还接受了详细的语音检查（听觉感知、视频频闪镜检查、声学分析、发音困难严重程度指数（DSI）、空气动力学测量）。几乎所有的54名患者（96.3%）由于吞咽问题而生活质量有限，48%由于声音问题。这两个值与口干的程度显着相关。在语音检查中，77.8%的DSI增加，三分之二的视频频闪镜检查异常。由于声音和吞咽功能的限制，SjS患者的生活质量受到了合理的损害。由于SjS不限制预期寿命，因此保持生活质量很重要。应检测作为生活质量损害的潜在原因的声音和吞咽问题，如果诊断出，应进行相应的治疗。
Sjögren’s syndrome (SjS) causes malfunction of the salivary and lacrimal glands. Consequently, patients suffer from xerostomia and keratoconjunctivitis sicca. This can further affect the voice and swallowing function resulting in an impaired quality of life. Aim of this study is the systematic evaluation of the impact on voice and swallowing-related quality of life in patients with SjS. SjS patients were classified according to the American–European Consensus Group (AECG) criteria; antibodies to Ro (SS-A) or La (SS-B) antigens were detected, ESSPRI was completed. We used the following quality of life questionnaires: EORTC QLQ H&N 35, Anderson Dysphagia Inventory (ADI) and Voice Handicap Index (VHI). Patients additionally received a detailed phoniatric examination (auditory perception, videostroboscopy, acoustic analysis, Dysphonia Severity Index (DSI), aerodynamics measurements). Almost all the 54 patients (96.3%) had a limited quality of life due to their swallowing problems and 48% due to their voice problems. Both values correlated significantly with the degree of xerostomia. In the phoniatric examination, 77.8% had an increased DSI and two-thirds had abnormalities in videostroboscopy. A reasonable impairment of quality of life in patients with SjS due to the limitations in voice and swallowing function was observed. As SjS does not limitate life expectancy, preservation of quality of life is important. Detection of voice and swallowing problems as potential reasons for quality of life impairment should be detected and, if diagnosed, treated accordingly.
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