Intracellular sterol dynamics.
Intracellular sterol dynamics.
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DOI：
10.1016/j.bbalip.2009.03.002
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发表时间：
2009-07
期刊：
影响因子：
--
通讯作者：
Maxfield FR
中科院分区：
文献类型：
--
作者：
Mesmin B;Maxfield FR
我们回顾了涉及胆固醇运输和分布的细胞机制。最近的研究提供了有关甾醇在细胞内分布的新信息，包括其跨双层分布的分析。胆固醇与其他脂质的相互作用及其参与各种运输过程将决定其在特定膜中的适当水平;使胆固醇在各种细胞内细胞器中分布不均匀。胆固醇含量很重要，因为胆固醇通过控制膜的物理化学性质以及关键的细胞事件（如信号转导和蛋白质运输）在膜中起着重要作用。胆固醇在细胞器之间的移动是高度动态的，并且可以通过囊泡和非囊泡过程来实现。各种研究分析了在这些过程中发挥重要作用的蛋白质，为我们提供了关于这两种运输途径在胆固醇运输中的相对重要性的新信息。尽管在许多运输途径中仍缺乏特征，但已详细描述了几种潜在的甾醇转运蛋白;因此，膜间甾醇转运的分子机制开始受到重视。
We review the cellular mechanisms implicated in cholesterol trafficking and distribution. Recent studies have provided new information about the distribution of sterols within cells, including analysis of its transbilayer distribution. The cholesterol interaction with other lipids and its engagement in various trafficking processes will determine its proper level in a specific membrane; making the cholesterol distribution uneven among the various intracellular organelles. The cholesterol content is important since cholesterol plays an essential role in membranes by controlling their physicochemical properties as well as key cellular events such as signal transduction and protein trafficking. Cholesterol movement between cellular organelles is highly dynamic, and can be achieved by vesicular and non-vesicular processes. Various studies have analyzed the proteins that play a significant role in these processes, giving us new information about the relative importance of these two trafficking pathways in cholesterol transport. Although still poorly characterized in many trafficking routes, several potential sterol transport proteins have been described in detail; as a result, molecular mechanisms for sterol transport among membranes start to be appreciated.
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影响因子：
4.8
作者：
Cheruku, Sunita R.;Xu, Zhi;Storch, Judith
通讯作者：
Storch, Judith
影响因子：
4.8
作者：
Arakawa, R;Yokoyama, S
通讯作者：
Yokoyama, S
影响因子：
5.6
作者：
Canagarajah, Bertram J.;Hummer, Gerhard;Hurley, James H.
通讯作者：
Hurley, James H.
DOI：
10.1038/newbio236011a0
发表时间：
1972-01-01
期刊：
NATURE-NEW BIOLOGY
影响因子：
--
作者：
BRETSCHER, MS
通讯作者：
BRETSCHER, MS
影响因子：
4
作者：
Beh, CT;Rine, J
通讯作者：
Rine, J