Balancing the fat: lipid droplets and human disease.

Balancing the fat: lipid droplets and human disease.
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DOI:
10.1002/emmm.201100671
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发表时间:
2013-07
影响因子:
11.1
通讯作者:
Walther, Tobias C.
Walther, Tobias C.
中科院分区:
医学1区
文献类型:
--
作者:
Krahmer, Natalie;Farese, Robert V., Jr.;Walther, Tobias C.

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脂滴(LDs)是动态的,细胞溶质的脂质储存细胞器中发现几乎所有的细胞类型。过多或过少的LD在过量或不足的脂肪储存导致许多不同的人类疾病。最近对LD生物学和LD蛋白功能的深入了解为这些代谢病理学的机制提供了新的线索。这些发现可能会为治疗与脂肪过多或过少相关的疾病提供机会。
Lipid droplets (LDs) are dynamic, cytosolic lipid-storage organelles found in nearly all cell types. Too many or too few LDs during excess or deficient fat storage lead to many different human diseases. Recent insights into LD biology and LD protein functions shed new light on mechanisms underlying those metabolic pathologies. These findings will likely provide opportunities for treatment of diseases associated with too much or too little fat.
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