Toward efficient biomechanical-based deformable image registration of lungs for image-guided radiotherapy.
Toward efficient biomechanical-based deformable image registration of lungs for image-guided radiotherapy.
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DOI：
10.1088/0031-9155/56/15/005
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发表时间：
2011-08-07
影响因子：
3.5
通讯作者：
Brock K
中科院分区：
文献类型：
--
作者：
Al-Mayah A;Moseley J;Velec M;Brock K
基于生物力学模型的变形配准技术在临床应用中的准确性和效率是关键。本研究的重点是评估在不损失准确性的情况下提高人肺的可变形图像配准的效率的潜力。利用14例肺癌患者的影像资料建立了三维有限元模型。每个模型由两个肺、肿瘤和外部身体组成。使用基于无摩擦表面的接触模型对肺在胸腔内的滑动进行建模。研究了单元类型、有限变形和弹性对计算精度和计算时间的影响。线性和四边形四面体单元用于线性和非线性几何分析。应用两种类型的材料特性，即：弹性和超弹性。使用代表分布在肺部的血管分叉点的许多解剖标志来检查四个模型中的每一个的准确性。配准误差不受元素类型或分析线性的显著影响，平均矢量误差约为2.8 mm。线性和非线性分析方法之间的位移差异计算所有肺节点和3.6 mm的最大值被发现在支气管树进入肺的入口附近的一个节点。位移差的95百分位数范围在0.4和0.8 mm之间。然而，分析所需的时间从二次单元非线性几何模型中的95 min减少到线性单元线性几何模型中的3.4 min。因此，使用具有线性弹性材料和线性几何形状的线性四面体元件对于对用于图像引导的放射治疗应用的肺的呼吸运动进行建模是优选的。
Both accuracy and efficiency are critical for the implementation of biomechanical model-based deformable registration into clinical practice. The focus of this investigation is to evaluate the potential of improving the efficiency of the deformable image registration of the human lungs without loss of accuracy. Three dimensional finite element models have been developed using image data of fourteen lung cancer patients. Each model consists of two lungs, tumor, and external body. Sliding of the lungs inside the chest cavity is modeled using a frictionless surface based contact model. The effect of type of element, finite deformation and elasticity on the accuracy and computing time are investigated. Linear and quadrilateral tetrahedral elements are used with linear and nonlinear geometric analysis. Two types of material properties are applied namely: elastic and hyperelastic. The accuracy of each of the four models is examined using a number of anatomical landmarks representing the vessels bifurcation points distributed across the lungs. The registration error is not significantly affected by element type or linearity of analysis with an average vector error of around 2.8 mm. The displacement differences between linear and nonlinear analysis methods are calculated for all lungs nodes and a maximum value of 3.6 mm is found in one of the nodes near the entrance of the bronchial tree into the lungs. The 95 percentile of displacement difference ranges between 0.4 and 0.8 mm. However, the time required for the analysis is reduced from 95 min in the quadratic elements nonlinear geometry model to 3.4 min in the linear element linear geometry model. Therefore using linear tetrahedral elements with linear elastic materials and linear geometry is preferable for modeling the breathing motion of lungs for image guided radiotherapy applications.
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影响因子：
3.8
作者：
LAIFOOK, SJ
通讯作者：
LAIFOOK, SJ
影响因子：
2.4
作者：
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通讯作者：
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DOI：
10.1016/s0360-3016(98)00130-8
发表时间：
1998-07-01
影响因子：
7
作者：
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通讯作者：
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DOI：
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发表时间：
2007-06-01
影响因子：
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作者：
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通讯作者：
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影响因子：
2.4
作者：
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通讯作者：
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