Local treatment of cancellous bone grafts with BMP-7 and zoledronate increases both the bone formation rate and bone density: a bone chamber study in rats.
Local treatment of cancellous bone grafts with BMP-7 and zoledronate increases both the bone formation rate and bone density: a bone chamber study in rats.
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DOI：
10.3109/17453674.2011.566138
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发表时间：
2011-04
影响因子：
3.7
通讯作者：
Tägil M
中科院分区：
文献类型：
--
作者：
Belfrage O;Flivik G;Sundberg M;Kesteris U;Tägil M
骨形态发生蛋白(BMP)等合成代谢物质可促进翻修手术中颗粒骨移植的重塑。另一方面，BMP促进分解代谢，并可能导致移植物和新形成的骨过早吸收。双膦酸盐可使破骨细胞失活，并可用于控制吸收。我们研究了两种药物的组合作为同种异体松质骨移植的局部混合物。取同种异体松质骨，冷冻干燥。在溶液中加入生理盐水、BMP-7、双膦酸唑来膦酸盐或BMP-7和唑来膦酸盐的组合。将移植物植入34只大鼠的胫骨近端。6周后取材，进行组织形态计量学评价。骨形态发生蛋白-7与唑来膦酸盐联用组的骨体积/总体积(BV/TV)为50%，生理盐水对照组为16%(p<；0.001)。唑来膦酸酯组BV/TV为56%，BMP组为14%。骨形态发生蛋白-7和唑来膦酸钠组的新骨植入距离分别为3.5m m和2.6m m，差异有统计学意义(p=0.002)。联合应用BMP-7和唑来磷酸钠后，保留的重建骨净量是对照组的4倍以上。像BMP-7这样的合成代谢药物可以与抗分解代谢的双膦酸盐作为局部植骨附件联合使用，这种组合可以增加重建完成后剩余的骨量。
The remodeling of morselized bone grafts in revision surgery can be enhanced by an anabolic substance such as a bone morphogenetic protein (BMP). On the other hand, BMPs boost catabolism and might cause a premature resorption, both of the graft and of the new-formed bone. Bisphosphonates inactivate osteoclasts and can be used to control the resorption. We studied a combination of both drugs as a local admix to a cancellous allograft. Cancellous bone allografts were harvested and freeze-dried. Either saline, BMP-7, the bisphosphonate zoledronate, or a combination of BMP-7 and zoledronate were added in solution. The grafts were placed in bone conduction chambers and implanted in the proximal tibia of 34 rats. The grafts were harvested after 6 weeks and evaluated by histomorphometry. Bone volume/total volume (BV/TV) was 50% in the grafts treated with the combination of BMP-7 and zoledronate and 16% in the saline controls (p < 0.001). In the zoledronate group BV/TV was 56%, and in the BMP group it was 14%. The ingrowth distance of new bone into the graft was 3.5 mm for the combination of BMP-7 and zoledronate and 2.6 mm in the saline control (p = 0.002). The net amount of retained remodeled bone was more than 4 times higher when BMP-7 and zoledronate were combined than in the controls. An anabolic drug like BMP-7 can be combined with an anti-catabolic bisphosphonate as local bone graft adjunct, and the combination increases the amount of remaining bone after remodeling is complete.
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影响因子：
4
作者：
Rabenda, V.;Mertens, R.;Reginster, J. -Y.
通讯作者：
Reginster, J. -Y.
影响因子：
2.8
作者：
McGee, MA;Findlay, DM;Toth, C
通讯作者：
Toth, C
DOI：
10.1080/000164702317281350
发表时间：
2002-01-01
期刊：
ACTA ORTHOPAEDICA SCANDINAVICA
影响因子：
--
作者：
Aspenberg, P;Åstrand, J
通讯作者：
Åstrand, J
影响因子：
4.1
作者：
Iwata, Ken;Li, Jiliang;Burr, David B.
通讯作者：
Burr, David B.
影响因子：
6.2
作者：
Okamoto, Mina;Murai, Junko;Tsumaki, Noriyuki
通讯作者：
Tsumaki, Noriyuki