Telomerase is an independent prognostic marker of overall survival in patients with colorectal cancer.
Telomerase is an independent prognostic marker of overall survival in patients with colorectal cancer.
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DOI：
10.1038/bjc.2012.602
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发表时间：
2013-02-05
影响因子：
8.8
通讯作者：
Pucciarelli, S.
中科院分区：
文献类型：
--
作者：
Bertorelle, R.;Briarava, M.;Rampazzo, E.;Biasini, L.;Agostini, M.;Maretto, I.;Lonardi, S.;Friso, M. L.;Mescoli, C.;Zagonel, V.;Nitti, D.;De Rossi, A.;Pucciarelli, S.
结直肠癌（CRC）是癌症相关死亡的重要原因。复发的预测是疾病治疗中的重要问题，特别是对于II期患者。端粒特异性逆转录酶（hTERT）是端粒酶复合物的催化成分，其水平沿着结直肠癌的进展而升高，但其预后价值尚不清楚。通过实时PCR研究了137例CRC患者肿瘤细胞中hTERT的表达。hTERT水平作为所有患者总生存期（OS）和50例II期患者亚组疾病复发的预后因素进行评估。中位hTERT水平为93.8拷贝（四分位数范围48-254）。高hTERT水平（高于中位数）患者的生存率明显低于低hTERT水平患者（低于中位数;对数秩检验P<0.0001;风险比（HR）=3.30（95%置信区间（CI）1.98-5.52）; P<0.0001）。高hTERT水平的预后价值与病理分期和微卫星不稳定性无关（HR=2.09（95% CI 1.20-3.64），P=0.009）。此外，在II期CRC中，高hTERT水平确定患者具有较高的疾病复发（HR=3.06（95%CI 1.03-9.04），P=0.043）和死亡（HR=3.24（95%CI 1.37-7.71），P=0.008）风险。hTERT水平是CRC患者OS的独立预后指标。此外，hTERT水平的评估可以改善II期CRC患者疾病复发风险的分层。
Colorectal cancer (CRC) is an important cause of cancer-related death. Prediction of recurrence is an important issue in the treatment of disease, particularly for stage II patients. The level of telomere-specific reverse transcriptase (hTERT), the catalytic component of the telomerase complex, increases along with CRC progression, but its prognostic value is still unclear. One hundred and thirty-seven CRC patients were studied for hTERT expression in tumour cells by real-time PCR. hTERT level was evaluated as a prognostic factor of overall survival (OS) in all patients and of disease recurrence in a subgroup of 50 stage II patients. The median hTERT level was 93.8 copies (interquartile range 48–254). Patients with high hTERT levels (above the median) showed a significantly worse survival than those with low hTERT levels (below the median; log-rank test P<0.0001; hazard ratio (HR)=3.30 (95% confidence interval (CI) 1.98–5.52); P<0.0001). The negative prognostic value of high hTERT level is independent of the pathological stage and microsatellite instability (HR=2.09 (95% CI 1.20–3.64), P=0.009). Moreover, in stage II CRC, high hTERT levels identified patients with a higher risk of disease recurrence (HR=3.06 (95% CI 1.03–9.04), P=0.043) and death (HR=3.24 (95% CI 1.37–7.71), P=0.008). hTERT level is an independent prognostic marker of OS in CRC patients. In addition, assessment of hTERT level could improve stratification of stage II CRC patients for the risk of disease recurrence.
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影响因子：
29.4
作者：
Boland CR;Goel A
通讯作者：
Goel A
影响因子：
11.5
作者：
Kelland, Lloyd
通讯作者：
Kelland, Lloyd
影响因子：
168.9
作者：
Cunningham, David;Atkin, Wendy;Starling, Naureen
通讯作者：
Starling, Naureen
影响因子：
3.4
作者：
Jose Safont, Maria;Gil, Mireia;Camps, Carlos
通讯作者：
Camps, Carlos
影响因子：
168.9
作者：
Gray, Richard;Barnwell, Jennifer;Kerr, David J.
通讯作者：
Kerr, David J.