Altered metabolism in right basal ganglia associated with asymptomatic neurocognitive impairment in HIV-infected individuals.
Altered metabolism in right basal ganglia associated with asymptomatic neurocognitive impairment in HIV-infected individuals.
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DOI：
10.1016/j.heliyon.2023.e23342
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发表时间：
2024-01-15
期刊：
影响因子：
4
通讯作者：
Shi, Yuxin
中科院分区：
文献类型：
--
作者：
Zhan, Yi;Cai, Dan-Chao;Liu, Ying;Song, Fengxiang;Shan, Fei;Song, Pengrui;Chen, Guochao;Zhang, Yijun;Wang, He;Shi, Yuxin
关键词：
只有少数研究关注无症状神经认知障碍（ANI）和认知正常的HIV感染者（PLWH）之间的代谢差异。本研究旨在通过磁共振波谱（MRS）检查基底神经节（BG）的脑代谢是否有可能区分ANI和认知正常的PLWH。根据神经心理学（NP）测验结果，将80例PLWH（37.4 ± 10.2岁）分为ANI组（HIV-ANI组，n = 31）和NP正常组（HIV-正常组，n = 49）。通过MRS从右侧BG比较组间的脑代谢，包括N-乙酰天冬氨酸和N-乙酰乙酰谷氨酸（tNAA）、肌酸和磷酸肌酸（tCr）以及含胆碱化合物（tCho）。介绍了三种代谢物的总价值。所有脑代谢均以其占总代谢的百分比进行评价。此外，MRS和NP和临床措施之间的相关性进行了评估。应用逻辑回归模型，并使用受试者工作曲线（ROC）分析比较模型和连续因素的AUC值。与HIV正常组相比，HIV ANI组tNAA/total降低，tCr/total升高（P < 0.05）。tNAA/total和tCr/total与NP评分相关（P < 0.05），尤其在语言流畅性、信息处理速度、学习和回忆方面（P < 0.05）。Logistic模型包括BG tCr/total、当前CD 4和PLWH感染年数。BG-tCr/总的AUC值为0.696，并不显著低于logistic模型（P < 0.01）。与认知正常的PLWH相比，在ANI组中发现了右侧BG中改变的脑代谢物，并进一步与NP缺陷相关。目前的研究结果表明，通过MRS评估的脑代谢物有可能区分ANI和认知正常的PLWH。
Only few studies have focused on the metabolite differences between asymptomatic neurocognitive impairment (ANI) and cognitively normal people living with HIV (PLWH). The current study aims to examine whether brain metabolisms in basal ganglia (BG) by magnetic resonance spectroscopy (MRS) were potential to discriminate ANI from cognitively normal PLWH. According to neuropsychological (NP) test, 80 PLWH (37.4 ± 10.2 years) were divided into ANI group (HIV-ANI, n = 31) and NP normal group (HIV-normal, n = 49). Brain metabolisms by MRS from right BG were compared between groups, including N-acetylaspartate and N-acetyl aspartylglutamate (tNAA), creatine and phosphocreatine (tCr), and choline-containing compounds (tCho). A total value of three metabolites were introduced. All brain metabolisms were evaluated as its percentage of total. Furthermore, correlations between MRS and NP and clinical measures were evaluated. A logistic regression model was applied, and the AUC values for the model and the continuous factors were compared using receiver operating curve (ROC) analysis. Compared to HIV-normal group, tNAA/total was lower and tCr/total was higher in the HIV-ANI group (P < 0.05). Both tNAA/total and tCr/total values were correlated with NP score (P < 0.05), especially in verbal fluency, speed of information processing, learning, and recall (P < 0.05). The logistic model included BG-tCr/total, current CD4 and infection years of PLWH. The AUC value for the BG-tCr/total was 0.696 and was not significantly lower than that for logistic model (P < 0.01). The altered brain metabolites in the right BG were found in the ANI group compared to PLWH with normal cognition, and further associated with NP deficits. The current findings indicated that brain metabolites assessed by MRS has the potential to discriminate ANI from cognitively normal PLWH.
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DOI：
10.1080/13854046.2012.740077
发表时间：
2013
期刊：
The Clinical neuropsychologist
影响因子：
--
作者：
Iudicello JE;Woods SP;Cattie JE;Doyle K;Grant I;HIV Neurobehavioral Research Program Group
通讯作者：
HIV Neurobehavioral Research Program Group
影响因子：
2.7
作者：
Masters MC;Ances BM
通讯作者：
Ances BM
影响因子：
11.8
作者：
Antinori, Andrea;Arendt, Gabriele;Munoz-Moreno, Jose A.
通讯作者：
Munoz-Moreno, Jose A.
影响因子：
9.9
作者：
Grant, Igor;Franklin, Donald R., Jr.;Heaton, Robert K.
通讯作者：
Heaton, Robert K.
DOI：
10.1017/s1355617704102130
发表时间：
2004-05-01
影响因子：
2.6
作者：
Heaton, RK;Marcotte, TD;Grant, I
通讯作者：
Grant, I