Risky decision-making in HIV-associated neurocognitive disorders (HAND).
Risky decision-making in HIV-associated neurocognitive disorders (HAND).
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DOI：
10.1080/13854046.2012.740077
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
HIV Neurobehavioral Research Program Group
中科院分区：
文献类型：
--
作者：
Iudicello JE;Woods SP;Cattie JE;Doyle K;Grant I;HIV Neurobehavioral Research Program Group
感染艾滋病毒的个体在决策方面表现出中度缺陷，但这种缺陷对日常功能的生态相关性以前没有被描述过。本研究旨在探讨HIV相关神经认知障碍（HAND）中风险决策障碍的程度、认知相关性和日常功能影响。参与者包括68名HIV+ HAND患者，78名HIV+ HAND患者和51名HIV-对照参与者，他们接受了爱荷华州赌博任务（IGT）以及全面的神经心理测试电池和自我报告措施，评估日常功能的各个方面。与其他两组相比，HIV+ HAND个体在IGT上的表现更差，最明显的是在最后三个试验区。在HIV+组中，在最后三个试验区中IGT表现与认知灵活性最密切相关，但与工具性日常生活活动（IADL），失业或药物不依从性的下降无关。虽然最后三个试验区组的整体IGT表现可能有助于诊断HAND中的决策障碍，但检查替代的、更具体的指标（例如，试验区之间的个体甲板选择）可能更有助于描述不良决策在艾滋病毒相关残疾中的作用，并应在未来的研究中进行审查。
Individuals infected with HIV show moderate deficits in decision-making, but the ecological relevance of such deficits on everyday functioning has not previously been described. This study sought to examine the magnitude, cognitive correlates, and everyday functioning impact of risky decision-making impairment in HIV-associated neurocognitive disorders (HAND). Participants included 68 HIV+ individuals with HAND, 78 HIV+ individuals without HAND, and 51 HIV- comparison participants, who were administered the Iowa Gambling Task (IGT) alongside a comprehensive neuropsychological test battery and self-report measures assessing aspects of everyday functioning. HIV+ individuals with HAND performed more poorly on the IGT relative to the other two groups, most notably during the last three trial blocks. Within the HIV+ group, IGT performance during the last three trial blocks was most strongly associated with cognitive flexibility, but was not significantly related to declines in instrumental activities of daily living (IADLs), unemployment, or medication non-adherence. While overall IGT performance across the last three trial blocks may be helpful diagnostically in identifying decision-making impairment in HAND, examination of alternate, more specific metrics (e.g., individual deck selections across trial blocks) may be more useful in delineating the role of poor decision-making in HIV-related disability, and should be examined in future research.
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DOI：
10.1016/j.jana.2008.10.005
发表时间：
2009-01
影响因子：
2
作者：
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DOI：
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作者：
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2008-01-01
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DOI：
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发表时间：
2012-01
影响因子：
2.6
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Grant, I.