The role of platelets in the pathogenesis of viral hemorrhagic fevers.

The role of platelets in the pathogenesis of viral hemorrhagic fevers.
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DOI:
10.1371/journal.pntd.0002858
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发表时间:
2014-06
影响因子:
3.8
通讯作者:
Salvato MS
Salvato MS
中科院分区:
医学2区
文献类型:
--
作者:
Zapata JC;Cox D;Salvato MS

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病毒性出血热(VHF)是一种急性人畜共患疾病,早期似乎会导致血小板破坏或功能障碍。在这里,我们提出了四种主要的方式病毒影响血小板的发育和功能和分子因子的新证据,优先诱导的家庭黄病毒科,布尼亚病毒科,沙粒病毒科,丝状病毒科的致病性成员。通过主要的医学电子数据库进行了系统检索,使用VHF中所有关于血小板的当前发现作为参数。此外,该评论还包含来自会议记录的信息。
Viral hemorrhagic fevers (VHF) are acute zoonotic diseases that, early on, seem to cause platelet destruction or dysfunction. Here we present the four major ways viruses affect platelet development and function and new evidence of molecular factors that are preferentially induced by the more pathogenic members of the families Flaviviridae, Bunyaviridae, Arenaviridae, and Filoviridae. A systematic search was performed through the main medical electronic databases using as parameters all current findings concerning platelets in VHF. Additionally, the review contains information from conference proceedings.
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