Daily Associations Between Alcohol Consumption and Antiretroviral Therapy (ART) Adherence Among HIV-Positive Men Who Have Sex With Men.
Daily Associations Between Alcohol Consumption and Antiretroviral Therapy (ART) Adherence Among HIV-Positive Men Who Have Sex With Men.
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DOI：
10.1007/s10461-022-03657-x
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发表时间：
2022-10
影响因子：
4.4
通讯作者：
Woolf-King, Sarah E.
中科院分区：
文献类型：
--
作者：
Sheinfil, Alan Z.;Foley, Jacklyn D.;Moskal, Dezarie;Dalton, Michelle R.;Firkey, Madison;Ramos, Jeremy;Maisto, Stephen A.;Woolf-King, Sarah E.
关键词：
饮酒是抗逆转录病毒治疗（ART）依从性欠佳的最强预测因子之一，然而，很少有研究调查饮酒和ART依从性在事件水平上的人内和人与人之间的关联。在该次要数据分析中，（N = 22）HIV阳性MSM前瞻性报告了42天的每日饮酒量和ART依从性。多水平模型表明：1）与参与者报告不饮酒的天数相比，参与者报告饮酒的天数与ART不依从的几率增加2.48相关，2）有一个非显著趋势表明参与者报告饮酒量高于自己平均水平的天数与ART不依从的几率增加相关。研究结果强调了结合干预措施的重要性，解决酒精消费和次优的ART坚持，并表明需要未来的研究，以调查酒精影响ART坚持的机制。
Alcohol consumption is one of the strongest predictors of suboptimal adherence to antiretroviral therapy (ART), however, there is little research that has investigated both within- and between-person associations of alcohol consumption and ART adherence at the event-level. In this secondary data-analysis, (N = 22) HIV-positive MSM prospectively reported daily alcohol consumption and ART adherence for 42-days. Multilevel models demonstrated 1) days in which participants reported consuming any alcohol was associated with 2.48 increased odds of ART non-adherence, compared to days in which participants reported no alcohol consumption, and 2) there was a non-significant trend indicating days in which participants reported consuming greater than their own average levels of alcohol was associated with increased odds of ART non-adherence. Findings highlight the importance of combining intervention efforts that address alcohol consumption and suboptimal ART adherence, and indicate a need for future research to investigate the mechanisms by which alcohol influences ART adherence.
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