Simultaneous quantitative susceptibility mapping (QSM) and R2* for high iron concentration quantification with 3D ultrashort echo time sequences: An echo dependence study.
Simultaneous quantitative susceptibility mapping (QSM) and R2* for high iron concentration quantification with 3D ultrashort echo time sequences: An echo dependence study.
复制标题
使用 3D 超短回波时间序列进行高铁浓度定量的同步定量磁化率绘图 (QSM) 和 R2：回波依赖性研究。
DOI：
10.1002/mrm.27062
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发表时间：
2018-04
影响因子：
3.3
通讯作者：
Du J
中科院分区：
文献类型：
--
作者：
Lu X;Ma Y;Chang EY;He Q;Searleman A;von Drygalski A;Du J
在高浓度氧化铁纳米颗粒（IONPs）环境下，评价三维超短回波时间定量敏感性作图（3D UTE-QSM）和R2*测量对回波的依赖性。利用3D UTE锥体序列进行了铁浓度范围为2至22 mM的幻影研究。利用获取的三维UTE数据，离线同时进行形态学偶极子反演（MEDI）和R2*单指数拟合的QSM处理。研究了UTE-QSM和R2*对回波间距（ΔTE）和首次回波时间（TE1）的依赖关系。UTE-QSM测量值与22 mM以内的铁浓度呈线性关系，最小TE1为0.032 ms， ΔTE小于0.1 ms。只有当TE1小于0.132 ms， ΔTE小于1.2 ms时，R2*与铁浓度在22 mM以内呈线性关系。具有MEDI加工的UTE-QSM表现出对ΔTE和TE1的强烈依赖，特别是在高铁浓度下。UTE-QSM对回波时间的选择比R2*测量更敏感。为了在高铁浓度下实现精确的QSM，需要超短的TE1和小的ΔTE。
To evaluate the echo dependence of three-dimensional ultrashort echo time quantitative susceptibility mapping (3D UTE-QSM) and R2* measurement in the setting of high concentrations of iron oxide nanoparticles (IONPs). A phantom study with iron concentrations ranging from 2 to 22 mM was performed using a 3D UTE Cones sequence. Simultaneous QSM processing with Morphology Enabled Dipole Inversion (MEDI) and R2* single exponential fitting were conducted offline with the acquired 3D UTE data. The dependence of UTE-QSM and R2* on echo spacing (ΔTE) and the first echo time (TE1) was investigated. A linear relationship was observed between UTE-QSM measurement and iron concentration up to 22 mM only with the minimal TE1 of 0.032 ms and ΔTE of less than 0.1 ms. A linear relationship was observed between R2* and iron concentration up to 22 mM only when TE1 was less than 0.132 ms and ΔTE was less than 1.2 ms. UTE-QSM with MEDI processing showed strong dependence on ΔTE and TE1, especially at high iron concentrations. UTE-QSM is more sensitive than R2* measurement to echo time selection. Both an ultrashort TE1 and a small ΔTE are needed in order to achieve accurate QSM for high iron concentrations.
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