Superparamagnetic iron oxide nanoparticles as MRI contrast agents for non-invasive stem cell labeling and tracking.
Superparamagnetic iron oxide nanoparticles as MRI contrast agents for non-invasive stem cell labeling and tracking.
复制标题
超顺磁性氧化铁纳米粒子作为 MRI 造影剂用于非侵入性干细胞标记和跟踪
作者：
Li L;Jiang W;Luo K;Song H;Lan F;Wu Y;Gu Z
干细胞在治疗多种人类疾病和失调方面具有巨大的前景。移植后体内干细胞的跟踪和监测可以为确定干细胞治疗的疗效提供重要信息。磁共振成像（MRI）与造影剂相结合被认为是活体干细胞追踪最有效、最安全的非侵入性技术。商业超顺磁性氧化铁纳米颗粒（SPION）在转染剂（TA）的帮助下已被应用于标记干细胞。然而，由于TAs的潜在毒性，人们更加关注开发具有特定表面涂层或功能部分的新型SPIONs，以在没有TAs的情况下促进有效的细胞内化。本文旨在总结SPION作为细胞MRI探针的设计和制备的最新进展，讨论其在干细胞标记和追踪中的应用和当前面临的问题，并为SPION在该领域的未来发展提供展望和解决方案。
Stem cells hold great promise for the treatment of multiple human diseases and disorders. Tracking and monitoring of stem cells in vivo after transplantation can supply important information for determining the efficacy of stem cell therapy. Magnetic resonance imaging (MRI) combined with contrast agents is believed to be the most effective and safest non-invasive technique for stem cell tracking in living bodies. Commercial superparamagnetic iron oxide nanoparticles (SPIONs) in the aid of transfection agents (TAs) have been applied to labeling stem cells. However, owing to the potential toxicity of TAs, more attentions have been paid to develop novel SPIONs with specific surface coating or functional moieties which facilitate effective cell internalization in the absence of TAs. This review aims to summarize the recent progress in the design and preparation of SPIONs as cellular MRI probes, to discuss their applications and current problems facing in stem cell labeling and tracking, and to offer perspectives and solutions for the future development of SPIONs in this field.
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DOI：
10.2967/jnumed.108.053546
发表时间：
2009-02
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Budde MD;Frank JA
通讯作者：
Frank JA
影响因子：
3.3
作者：
Bowen, CV;Zhang, XW;Rutt, BK
通讯作者：
Rutt, BK
影响因子：
14
作者：
Andreas, Kristin;Georgieva, Radostina;Ringe, Jochen
通讯作者：
Ringe, Jochen
影响因子：
3.3
作者：
Berry, I;Benderbous, S;LeBihan, D
通讯作者：
LeBihan, D
影响因子：
3.8
作者：
Chen, Ying-Chun;Hsiao, Jong-Kai;Huang, Dong-Ming
通讯作者：
Huang, Dong-Ming