An AUTS2-Polycomb complex activates gene expression in the CNS.
An AUTS2-Polycomb complex activates gene expression in the CNS.
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DOI：
10.1038/nature13921
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发表时间：
2014-12-18
期刊：
影响因子：
64.8
通讯作者：
Reinberg, Danny
中科院分区：
文献类型：
--
作者：
Gao, Zhonghua;Lee, Pedro;Stafford, James M.;von Schimmelmann, Melanie;Schaefer, Anne;Reinberg, Danny
Naturally occurring variations of Polycomb Repressive Complex 1 (PRC1) comprise a core assembly of Polycomb group proteins and additional factors that include, surprisingly, Autism Susceptibility Candidate 2 (AUTS2). While AUTS2 is often disrupted in patients with neuronal disorders, the underlying mechanism is unclear. We investigated the role of AUTS2 as part of a previously identified PRC1 complex (PRC1-AUTS2), and in the context of neurodevelopment. In contrast to the canonical role of PRC1 in gene repression, PRC1-AUTS2 activates transcription. Biochemical studies demonstrated that the CK2 component of PRC1-AUTS2 thwarts PRC1 repressive activity while AUTS2-mediated recruitment of P300 leads to gene activation. ChIP-seq demonstrated that AUTS2 regulates neuronal gene expression through promoter association. Conditional targeting of Auts2 in the mouse central nervous system (CNS) leads to various developmental defects. These findings reveal a natural means of subverting PRC1 activity, linking key epigenetic modulators with neuronal functions and diseases.
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影响因子：
6.8
作者：
James SJ;Shpyleva S;Melnyk S;Pavliv O;Pogribny IP
通讯作者：
Pogribny IP
影响因子：
11
作者：
Ladd-Acosta, C.;Hansen, K. D.;Briem, E.;Fallin, M. D.;Kaufmann, W. E.;Feinberg, A. P.
通讯作者：
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影响因子：
64.5
作者：
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通讯作者：
Pirrotta, V
DOI：
10.1016/j.gep.2009.11.005
发表时间：
2010-01
期刊：
Gene expression patterns : GEP
影响因子：
--
作者：
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通讯作者：
Hevner RF
影响因子：
56.9
作者：
Cao, R;Wang, LJ;Zhang, Y
通讯作者：
Zhang, Y