Photoacoustic mediated multifunctional tumor antigen trapping nanoparticles inhibit the recurrence and metastasis of ovarian cancer by enhancing tumor immunogenicity.
Photoacoustic mediated multifunctional tumor antigen trapping nanoparticles inhibit the recurrence and metastasis of ovarian cancer by enhancing tumor immunogenicity.
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光声介导的多功能肿瘤抗原捕获纳米颗粒通过增强肿瘤免疫原性抑制卵巢癌复发和转移。
DOI：
10.1186/s12951-022-01682-5
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发表时间：
2022-11-03
影响因子：
10.2
通讯作者：
Chang S
中科院分区：
文献类型：
--
作者：
Zhong X;Li C;Zhao G;Li M;Chen S;Cao Y;Wang Q;Sun J;Zhu S;Chang S
肿瘤免疫原性低下是肿瘤免疫治疗的主要瓶颈之一。增强肿瘤免疫原性可以通过增加抗原暴露和提呈，建立炎性微环境来提高肿瘤免疫治疗的疗效。利用吲哚青绿(ICG)、氢氧化铝(Al(OH)3)和草酸铂(OXA)(PPIAO)制备了一种多功能的抗原捕获纳米粒子，用于肿瘤光声/超声双模成像和治疗。光热/光动力疗法和化疗的结合通过肿瘤细胞的免疫原性死亡诱导肿瘤抗原的暴露和释放。氢氧化铝及时捕获和储存抗原，使树突状细胞能够在时空上识别和呈递这些抗原。在卵巢肿瘤模型中，光声介导的PPIAO纳米粒子联合治疗实现了从冷瘤到热瘤的转变，促进了体内更多的CD8+T淋巴细胞的激活和瘤内的侵袭，并成功地抑制了原发和转移肿瘤的生长。治疗后的肿瘤组织产生了原位肿瘤疫苗效应，帮助小鼠防止肿瘤细胞复发。本研究为更好地治疗转移和复发肿瘤提供了一种简单有效的个体化肿瘤疫苗策略。所开发的多功能肿瘤抗原捕获纳米颗粒可能成为集成多模式成像监测、肿瘤治疗和肿瘤疫苗免疫治疗的一个很有前途的纳米平台。网上版载有补充材料，可在10.1186/s12951-022-01682-5查阅。
The hypoimmunogenicity of tumors is one of the main bottlenecks of cancer immunotherapy. Enhancing tumor immunogenicity can improve the efficacy of tumor immunotherapy by increasing antigen exposure and presentation, and establishing an inflammatory microenvironment. Here, a multifunctional antigen trapping nanoparticle with indocyanine green (ICG), aluminum hydroxide (Al(OH)3) and oxaliplatin (OXA) (PPIAO) has been developed for tumor photoacoustic/ultrasound dual-modality imaging and therapy. The combination of photothermal/photodynamic therapy and chemotherapy induced tumor antigen exposure and release through immunogenic death of tumor cells. A timely capture and storage of antigens by aluminum hydroxide enabled dendritic cells to recognize and present those antigens spatiotemporally. In an ovarian tumor model, the photoacoustic-mediated PPIAO NPs combination therapy achieved a transition from “cold tumor” to “hot tumor” that promoted more CD8+ T lymphocytes activation in vivo and intratumoral infiltration, and successfully inhibited the growth of primary and metastatic tumors. An in situ tumor vaccine effect was produced from the treated tumor tissue, assisting mice against the recurrence of tumor cells. This study provided a simple and effective personalized tumor vaccine strategy for better treatment of metastatic and recurrent tumors. The developed multifunctional tumor antigen trapping nanoparticles may be a promising nanoplatform for integrating multimodal imaging monitoring, tumor treatment, and tumor vaccine immunotherapy. The online version contains supplementary material available at 10.1186/s12951-022-01682-5.
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影响因子：
9
作者：
Fucikova J;Kepp O;Kasikova L;Petroni G;Yamazaki T;Liu P;Zhao L;Spisek R;Kroemer G;Galluzzi L
通讯作者：
Galluzzi L
DOI：
10.1016/j.jconrel.2013.10.032
发表时间：
2014-01-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Li X;Aldayel AM;Cui Z
通讯作者：
Cui Z
影响因子：
64.8
作者：
通讯作者：
--
癌症免疫疗法。树突状细胞疫苗增加了黑色素瘤新抗原特异性T细胞的广度和多样性。
DOI：
10.1126/science.aaa3828
发表时间：
2015-05-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Carreno BM;Magrini V;Becker-Hapak M;Kaabinejadian S;Hundal J;Petti AA;Ly A;Lie WR;Hildebrand WH;Mardis ER;Linette GP
通讯作者：
Linette GP
影响因子：
5.5
作者：
Colaprico, Annalisa;Senesi, Silvia;O'Hagan, Derek T.
通讯作者：
O'Hagan, Derek T.