Single neuron responses in amygdala of alert monkey during complex sensory stimulation with affective significance
Single neuron responses in amygdala of alert monkey during complex sensory stimulation with affective significance
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具有情感意义的复杂感觉刺激期间警觉猴杏仁核的单神经元反应
DOI：
10.1523/jneurosci.08-10-03570.1988
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Hitoo Nishino
中科院分区：
文献类型：
--
作者：
H. Nishijo;T. Ono;Hitoo Nishino
在其他缺陷中，杏仁核切除术损害了动物识别刺激的情感意义的能力。在本研究中，杏仁核（AM）的神经元活动记录从警觉的猴子，而他们执行的任务，导致奖励或厌恶刺激的介绍。585 AM神经元测试，312（53.3%）响应至少一个刺激的一个或多个5个主要群体：40视觉相关，26听力相关，41摄食相关，117多模态，和14选择性。摄食相关神经元根据它们对其他刺激的反应进行细分：口腔感觉，口腔感觉加视觉，口腔感觉加听觉。根据它们对刺激的情感意义的反应，视觉和听觉相关类别中的神经元分为2个亚类：vis-I（26/40），vis-II（14/40），aud-I（8/26）和aud-II（18/26）。所有4种亚型通常对不熟悉的刺激有反应，但很少对中性的熟悉刺激有反应。vis-I型和aud-I型对正面和负面的熟悉刺激都有反应。类型vis-II和aud-II对某些熟悉的负刺激有反应，但对熟悉的正刺激没有反应。在vis-I神经元中，对可口食物的反应比对不太可口的食物的反应更强。视觉相关，听觉相关和多模态类别内没有神经元只对积极或消极刺激作出反应。在27个口腔感觉神经元中，9个用盐水或盐腌食物进行测试，8个以与正常食物或液体（水或果汁）相同的方式对通常厌恶的口腔感觉刺激作出反应。与口腔感觉神经元相反，4个口腔感觉加视觉和所有4个选择性神经元测试的所有反应，以及压杆行为，通过改变食物的情感意义来调制。这些结果表明，AM是基于联想学习和记忆的刺激-情感联想的候选者之一。
Among other deficits, amygdalectomy impairs the ability of the animal to recognize the affective significance of a stimulus. In the present study, neuronal activity in the amygdala (AM) was recorded from alert monkeys while they performed tasks leading to the presentation of rewarding or aversive stimuli. Of 585 AM neurons tested, 312 (53.3%) responded to at least one stimulus in one or more of 5 major groups: 40 vision related, 26 audition related, 41 ingestion related, 117 multimodal, and 14 selective. Ingestion-related neurons were subdivided according to their responses to other stimuli: oral sensory, oral sensory plus vision, and oral sensory plus audition. Depending upon their responsiveness to the affective significance of the stimuli, neurons in the vision- and audition-related categories were divided into 2 subclasses: vis-I (26/40), vis-II (14/40), aud-I (8/26), and aud- II (18/26). All 4 subtypes usually responded to unfamiliar stimuli but seldom responded to neutral familiar stimuli. Types vis-I and aud-I responded to both positive and negative familiar stimuli. Types vis-II and aud-II responded to certain familiar negative stimuli but not to familiar positive stimuli. In vis-I neurons, responses were stronger for palatable foods than for less palatable foods. No neurons within vision-related, audition-related, and multimodal categories responded solely to positive or to negative stimuli. Of the 27 oral sensory neurons 9 were tested with saline or salted food, and 8 responded to normally aversive oral sensory stimuli in the same manner as they did to normal food or liquid (water or juice). In contrast to oral sensory neurons, all responses of 4 oral sensory-plus-vision and all of 4 selective neurons tested, as well as bar pressing behavior, were modulated by altering the affective significance of the food. These results suggest that the AM is one of the candidates for stimulus- affective association based on associative learning and memory.
遗忘症的神经解剖学：杏仁核-海马与颞干。
DOI：
10.1126/science.6890713
发表时间：
1982
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Zola-Morgan,S;Squire,LR;Mishkin,M
通讯作者：
Mishkin,M